EM Data Bank

{{infobox biodatabase

|title = EMDataBank.org

|logo =File:Database.png

|description = Unified Data Resource for CryoEM.

|center = European Bioinformatics Institute (UK site) AND Rutgers University (USA site)

|laboratory = PDBe & RCSB PDB

|citation = Lawson & al. (2011){{cite journal |last1=Lawson |first1=Catherine L |last2=Baker |first2=Matthew L |last3=Best |first3=Christoph |last4=Bi |first4=Chunxiao |last5=Dougherty |first5=Matthew |last6=Feng |first6=Powei |last7=van Ginkel |first7=Glen |last8=Devkota |first8=Batsal |last9=Lagerstedt |first9=Ingvar |last10=Ludtke |first10=Steven J |last11=Newman |first11=Richard H |last12=Oldfield |first12=Tom J |last13=Rees |first13=Ian |last14=Sahni |first14=Gaurav |last15=Sala |first15=Raul |last16=Velankar |first16=Sameer |last17=Warren |first17=Joe |last18=Westbrook |first18=John D |last19=Henrick |first19=Kim |last20=Kleywegt |first20=Gerard J |last21=Berman |first21=Helen M |last22=Chiu |first22=Wah |display-authors=3 |date=January 2011 |title=EMDataBank.org: unified data resource for CryoEM |journal=Nucleic Acids Research |volume=39 |issue=suppl 1 |pages=D456-464 |pmid=20935055 |doi=10.1093/nar/gkq880 |pmc=3013769}}

|released = 2002

|standard =

|format =

|url ={{URL|ebi.ac.uk/emdb}}

|download =

|webservice =

|sql =

|sparql =

|webapp =

|standalone =

|license =

|versioning =

|frequency =

|curation =

|bookmark =

|version=

}}The EM Data Bank or Electron Microscopy Data Bank (EMDB) collects 3D EM maps and associated experimental data determined using electron microscopy of biological specimens. It was established in 2002 at the MSD/PDBe group of the European Bioinformatics Institute (EBI), where the European site of the EMDataBank.org consortium is located.{{Cite web|last=EMDB|title=Electron Microscopy Data Bank|url=https://www.ebi.ac.uk/emdb/about|access-date=2021-08-05|website=Electron Microscopy Data Bank|language=en}} {{As of|2015}}, the resource contained over 2,600 entries with a mean resolution of 15Å.{{cite journal |title=Navigating 3D electron microscopy maps with EM-SURFER |last1=Esquivel-Rodríguez |first1=J |last2=Xiong |first2=Y |last3=Han |first3=X |last4=Guang |first4=S |last5=Christoffer |first5=C |last6=Kihara |first6=D |display-authors=3 |journal=BMC Bioinform. |date=30 May 2015 |volume=16 |issue=181 |page=181 |doi=10.1186/s12859-015-0580-6 |pmid=26025554 |pmc=4448178 |doi-access=free }}

Deposition of data was originally via the EMdep deposition interface, but since 2016 deposition of data has been incorporated into the wwPDB OneDep interface.{{cite journal |title=OneDep: Unified wwPDB System for Deposition, Biocuration, and Validation of Macromolecular Structures in the PDB Archive |pmid=28190782 | doi=10.1016/j.str.2017.01.004 | pmc=5360273 |volume=25 |journal=Structure |pages=536–545 | last1 = Young | first1 = JY | last2 = Westbrook | first2 = JD | last3 = Feng | first3 = Z | last4 = Sala | first4 = R | last5 = Peisach | first5 = E | last6 = Oldfield | first6 = TJ | last7 = Sen | first7 = S | last8 = Gutmanas | first8 = A | last9 = Armstrong | first9 = DR | last10 = Berrisford | first10 = JM | last11 = Chen | first11 = L | last12 = Chen | first12 = M | last13 = Di Costanzo | first13 = L | last14 = Dimitropoulos | first14 = D | last15 = Gao | first15 = G | last16 = Ghosh | first16 = S | last17 = Gore | first17 = S | last18 = Guranovic | first18 = V | last19 = Hendrickx | first19 = PM | last20 = Hudson | first20 = BP | last21 = Igarashi | first21 = R | last22 = Ikegawa | first22 = Y | last23 = Kobayashi | first23 = N | last24 = Lawson | first24 = CL | last25 = Liang | first25 = Y | last26 = Mading | first26 = S | last27 = Mak | first27 = L | last28 = Mir | first28 = MS | last29 = Mukhopadhyay | first29 = A | last30 = Patwardhan | first30 = A | last31 = Persikova | first31 = I | last32 = Rinaldi | first32 = L | last33 = Sanz-Garcia | first33 = E | last34 = Sekharan | first34 = MR | last35 = Shao | first35 = C | last36 = Swaminathan | first36 = GJ | last37 = Tan | first37 = L | last38 = Ulrich | first38 = EL | last39 = van Ginkel | first39 = G | last40 = Yamashita | first40 = R | last41 = Yang | first41 = H | last42 = Zhuravleva | first42 = MA | last43 = Quesada | first43 = M | last44 = Kleywegt | first44 = GJ | last45 = Berman | first45 = HM | last46 = Markley | first46 = JL | last47 = Nakamura | first47 = H | last48 = Velankar | first48 = S | last49 = Burley | first49 = SK|year=2017 |issue=3 }}

Under the NIH Unified Data Resource for CryoEM, the Research Collaboration for Structural Biology (RCSB) also acts as a deposition, data processing and distribution center for EMDB data, while the National Center for Macromolecular Imaging (NCMI) is a collaborative partner in providing services and tools concerning the EMDB.

EM Data Bank also provides the EMsearch search tool and data can also be queried at RCSB, EMBL-EBI and PDBj.

EMDB is an archive for three-dimensional density maps of all types of biological assemblies, including ribosomes, chaperones, polymerases, multifunctional enzymes and viruses. Viper EMDB at Scripps is a separate database for three-dimensional EM maps of viruses.

To compare and assess methods for the new generation of higher resolution (better than 5Å) structures, the EMDB has hosted the first CryoEM Map Challenge and CryoEM Model Challenge, reported in a special issue of the Journal of Structural Biology.{{Cite journal|last=|first=|date=2018|editor-last=Lawson|editor-first=Catherine|editor2-last=Chiu|editor2-first=Wah|title=The CryoEM Structure Map and Model Challenges|url=https://journals.elsevier.com/journal-of-structural-biology/thematic-collections/the-cryoem-structure-map-and-model-challenges|journal=Journal of Structural Biology|volume=204|issue=1|pages=|doi=|issn=1047-8477}}