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ENTPD3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Ectonucleoside triphosphate diphosphohydrolase 3 is an enzyme that in humans is encoded by the ENTPD3 gene.{{cite journal | vauthors = Chadwick BP, Frischauf AM | title = The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster | journal = Genomics | volume = 50 | issue = 3 | pages = 357–67 |date=Oct 1998 | pmid = 9676430 | doi = 10.1006/geno.1998.5317 }}{{cite web | title = Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=956}}

ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.{{cite web | title = Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=956}}

References

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Further reading

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  • {{cite journal | vauthors=Munkonda MN, Kauffenstein G, Kukulski F |title=Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists. |journal=Biochem. Pharmacol. |volume=74 |issue= 10 |pages= 1524–34 |year= 2007 |pmid= 17727821 |doi= 10.1016/j.bcp.2007.07.033 |display-authors=etal}}
  • {{cite journal | vauthors=Ivanenkov VV, Meller J, Kirley TL |title=Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling. |journal=Biochemistry |volume=44 |issue= 25 |pages= 8998–9012 |year= 2005 |pmid= 15966724 |doi= 10.1021/bi047487z }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Yang F, Hicks-Berger CA, Smith TM, Kirley TL |title=Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions. |journal=Biochemistry |volume=40 |issue= 13 |pages= 3943–50 |year= 2001 |pmid= 11300774 |doi=10.1021/bi002711f }}
  • {{cite journal | vauthors=Smith TM, Lewis Carl SA, Kirley TL |title=Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase. |journal=Biochemistry |volume=38 |issue= 18 |pages= 5849–57 |year= 1999 |pmid= 10231536 |doi= 10.1021/bi990171k }}
  • {{cite journal | vauthors=Smith TM, Kirley TL |title=Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1. |journal=Biochim. Biophys. Acta |volume=1386 |issue= 1 |pages= 65–78 |year= 1998 |pmid= 9675246 |doi= 10.1016/s0167-4838(98)00063-6}}
  • {{cite journal | vauthors=Chadwick BP, Frischauf AM |title=Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes. |journal=Mamm. Genome |volume=8 |issue= 9 |pages= 668–72 |year= 1997 |pmid= 9271669 |doi=10.1007/s003359900534 |s2cid=42644202 }}

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