ENTPD5
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Ectonucleoside triphosphate diphosphohydrolase 5 is an enzyme that in humans is encoded by the ENTPD5 gene.{{cite journal | vauthors = Chadwick BP, Frischauf AM | title = Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes | journal = Mamm Genome | volume = 8 | issue = 9 | pages = 668–72 |date=Oct 1997 | pmid = 9271669 | doi =10.1007/s003359900534 | s2cid = 42644202 }}{{cite journal | vauthors = Chadwick BP, Frischauf AM | title = The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster | journal = Genomics | volume = 50 | issue = 3 | pages = 357–67 |date=Oct 1998 | pmid = 9676430 | doi = 10.1006/geno.1998.5317 }}{{cite web | title = Entrez Gene: ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=957}}
ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.
References
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Further reading
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- {{cite journal | vauthors=Mulero JJ, Yeung G, Nelken ST, Ford JE |title=CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20064–7 |year= 1999 |pmid= 10400613 |doi=10.1074/jbc.274.29.20064 |doi-access=free }}
- {{cite journal | author=Recio JA |title=The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells |journal=Mol. Carcinog. |volume=27 |issue= 3 |pages= 229–36 |year= 2000 |pmid= 10708485 |doi=10.1002/(SICI)1098-2744(200003)27:3<229::AID-MC10>3.0.CO;2-Z |name-list-style=vanc| author2=Zambrano N | author3=Peña L | display-authors=3 | last4=Reig | first4=Juan A. | last5=Rhoads | first5=Allen | last6=Rouzaut | first6=Ana | last7=Notario | first7=Vicente |s2cid=21222716 }}
- {{cite journal | author=Mulero JJ |title=Biochemical characterization of CD39L4 |journal=Biochemistry |volume=39 |issue= 42 |pages= 12924–8 |year= 2000 |pmid= 11041857 |doi=10.1021/bi000960y |name-list-style=vanc| author2=Yeung G | author3=Nelken ST | display-authors=3 | last4=Bright | first4=Jessica M. | last5=McGowan | first5=Daniel W. | last6=Ford | first6=John E. }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Blánquez MJ |title=Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia |journal=Mol. Carcinog. |volume=35 |issue= 4 |pages= 186–95 |year= 2003 |pmid= 12489110 |doi= 10.1002/mc.10091 |name-list-style=vanc| author2=Regadera J | author3=Mariño J | display-authors=3 | last4=Newman | first4=Robert E. | last5=Notario | first5=Vicente |s2cid=24074840 |doi-access=free }}
- {{cite journal | vauthors=Murphy-Piedmonte DM, Crawford PA, Kirley TL |title=Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase |journal=Biochim. Biophys. Acta |volume=1747 |issue= 2 |pages= 251–9 |year= 2005 |pmid= 15698960 |doi= 10.1016/j.bbapap.2004.11.017 }}
- {{cite journal | author=Liu T |title=Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 |name-list-style=vanc| author2=Qian WJ | author3=Gritsenko MA | display-authors=3 | last4=Camp | first4=David G. | last5=Monroe | first5=Matthew E. | last6=Moore | first6=Ronald J. | last7=Smith | first7=Richard D. }}
- {{cite journal | author=Regadera J |title=PCPH expression is an early event in the development of testicular germ cell tumors |journal=Int. J. Oncol. |volume=28 |issue= 3 |pages= 595–604 |year= 2006 |pmid= 16465363 |doi= 10.3892/ijo.28.3.595|name-list-style=vanc| author2=Blánquez MJ | author3=González-Peramato P | display-authors=3 | last4=Nistal | first4=M | last5=Miller | first5=JC | last6=Tirado | first6=OM | last7=Notario | first7=V | doi-access=free }}
- {{cite journal | author=Villar J |title=PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism |journal=Cancer Res. |volume=67 |issue= 22 |pages= 10859–68 |year= 2007 |pmid= 18006831 |doi= 10.1158/0008-5472.CAN-07-2041 |name-list-style=vanc| author2=Arenas MI | author3=MacCarthy CM | display-authors=3 | last4=Blanquez | first4=M. J. | last5=Tirado | first5=O. M. | last6=Notario | first6=V. | doi-access=free}}
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