EPHA6

{{Short description|Protein-coding gene in the species Homo sapiens}}

Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.{{cite journal | vauthors = Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S | title = The protein kinase complement of the human genome | journal = Science | volume = 298 | issue = 5600 | pages = 1912–34 | date = December 2002 | pmid = 12471243 | doi = 10.1126/science.1075762 | bibcode = 2002Sci...298.1912M | s2cid = 26554314 }}{{cite web | title = Entrez Gene: EPHA6 EPH receptor A6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=285220}}

EphA6 may serve an important role in breast carcinogenesis and may pose as a novel prognostic indicator and therapeutic target for breast cancer, particularly in patients with steroid receptor negative expression and HER‑2 overexpression{{cite journal | vauthors = Zhou D, Ren K, Wang J, Ren H, Yang W, Wang W, Li Q, Liu X, Tang F | title = Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer | journal = Oncology Letters | volume = 15 | issue = 4 | pages = 5257–5263 | date = April 2018 | pmid = 29552165 | pmc = 5840743 | doi = 10.3892/ol.2018.7919 }}

References

{{cite book | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=10.1016/S0074-7696(00)96005-4 |series=International Review of Cytology |isbn=978-0-12-364600-2 }}
{{cite journal | vauthors = Xu Q, Mellitzer G, Wilkinson DG | title = Roles of Eph receptors and ephrins in segmental patterning | journal = Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences | volume = 355 | issue = 1399 | pages = 993–1002 | date = July 2000 | pmid = 11128993 | pmc = 1692797 | doi = 10.1098/rstb.2000.0635 }}
{{cite journal | vauthors = Nakamoto T, Kain KH, Ginsberg MH | title = Neurobiology: New connections between integrins and axon guidance | journal = Current Biology | volume = 14 | issue = 3 | pages = R121-3 | date = February 2004 | pmid = 14986683 | doi = 10.1016/j.cub.2004.01.020 | s2cid = 2957639 | doi-access = free | bibcode = 2004CBio...14.R121N }}
{{cite journal | vauthors = Yamaguchi Y, Pasquale EB | title = Eph receptors in the adult brain | journal = Current Opinion in Neurobiology | volume = 14 | issue = 3 | pages = 288–96 | date = June 2004 | pmid = 15194108 | doi = 10.1016/j.conb.2004.04.003 | s2cid = 26196696 }}
{{cite journal | vauthors = Murai KK, Pasquale EB | title = Eph receptors, ephrins, and synaptic function | journal = The Neuroscientist | volume = 10 | issue = 4 | pages = 304–14 | date = August 2004 | pmid = 15271258 | doi = 10.1177/1073858403262221 | s2cid = 23900846 }}
{{cite journal | vauthors = Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD | title = Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis | journal = Neuron | volume = 17 | issue = 1 | pages = 9–19 | date = July 1996 | pmid = 8755474 | doi = 10.1016/S0896-6273(00)80276-7 | s2cid = 1075856 | doi-access = free }}
{{cite journal | vauthors = Aasheim HC, Munthe E, Funderud S, Smeland EB, Beiske K, Logtenberg T | title = A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes | journal = Blood | volume = 95 | issue = 1 | pages = 221–30 | date = January 2000 | pmid = 10607706 | doi = 10.1182/blood.V95.1.221 }}
{{cite journal | vauthors = Prevost N, Woulfe D, Tanaka T, Brass LF | title = Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 14 | pages = 9219–24 | date = July 2002 | pmid = 12084815 | pmc = 123121 | doi = 10.1073/pnas.142053899 | bibcode = 2002PNAS...99.9219P | doi-access = free }}
{{cite journal | vauthors = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Research | volume = 13 | issue = 10 | pages = 2265–70 | date = October 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 }}
{{cite journal | vauthors = Hafner C, Schmitz G, Meyer S, Bataille F, Hau P, Langmann T, Dietmaier W, Landthaler M, Vogt T | title = Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers | journal = Clinical Chemistry | volume = 50 | issue = 3 | pages = 490–9 | date = March 2004 | pmid = 14726470 | doi = 10.1373/clinchem.2003.026849 | doi-access = free }}

External links

{{PDBe-KB2|Q62413|Mouse Ephrin type-A receptor 6}}

Category:Tyrosine kinase receptors

EPHA6

References

Further reading

External links