EPHA8

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.

EPHA8 has been shown to interact with FYN.{{cite journal | vauthors = Choi S, Park S | title = Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity | journal = Oncogene | volume = 18 | issue = 39 | pages = 5413–22 | date = Sep 1999 | pmid = 10498895 | doi = 10.1038/sj.onc.1202917 | s2cid = 11001580 | doi-access = }}

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• {{cite journal | vauthors = Flanagan JG, Vanderhaeghen P | title = The ephrins and Eph receptors in neural development. | journal = Annu. Rev. Neurosci. | volume = 21 | pages = 309–45 | year = 1998 | pmid = 9530499 | doi = 10.1146/annurev.neuro.21.1.309 }}
• {{cite journal | vauthors = Holland SJ, Peles E, Pawson T, Schlessinger J | title = Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta. | journal = Curr. Opin. Neurobiol. | volume = 8 | issue = 1 | pages = 117–27 | year = 1998 | pmid = 9568399 | doi = 10.1016/S0959-4388(98)80015-9 | s2cid = 34141508 | doi-access = free }}
• {{cite journal | vauthors = Zhou R | title = The Eph family receptors and ligands. | journal = Pharmacol. Ther. | volume = 77 | issue = 3 | pages = 151–81 | year = 1998 | pmid = 9576626 | doi = 10.1016/S0163-7258(97)00112-5 }}
• {{cite journal | vauthors = Holder N, Klein R | title = Eph receptors and ephrins: effectors of morphogenesis. | journal = Development | volume = 126 | issue = 10 | pages = 2033–44 | year = 1999 | doi = 10.1242/dev.126.10.2033 | pmid = 10207129 }}
• {{cite book | vauthors = Wilkinson DG | title = Eph receptors and ephrins: regulators of guidance and assembly. | journal = Int. Rev. Cytol. | volume = 196 | pages = 177–244 | year = 2000 | pmid = 10730216 | doi = 10.1016/S0074-7696(00)96005-4 | series = International Review of Cytology | isbn = 978-0-12-364600-2 }}
• {{cite journal | vauthors = Xu Q, Mellitzer G, Wilkinson DG | title = Roles of Eph receptors and ephrins in segmental patterning. | journal = Philos. Trans. R. Soc. Lond. B Biol. Sci. | volume = 355 | issue = 1399 | pages = 993–1002 | year = 2001 | pmid = 11128993 | pmc = 1692797 | doi = 10.1098/rstb.2000.0635 }}
• {{cite journal | vauthors = Wilkinson DG | title = Multiple roles of EPH receptors and ephrins in neural development. | journal = Nat. Rev. Neurosci. | volume = 2 | issue = 3 | pages = 155–64 | year = 2001 | pmid = 11256076 | doi = 10.1038/35058515 | s2cid = 205014301 }}
• {{cite journal | vauthors = Nakamoto T, Kain KH, Ginsberg MH | title = Neurobiology: New connections between integrins and axon guidance. | journal = Curr. Biol. | volume = 14 | issue = 3 | pages = R121–3 | year = 2004 | pmid = 14986683 | doi = 10.1016/j.cub.2004.01.020 | s2cid = 2957639 | doi-access = free | bibcode = 2004CBio...14.R121N }}
• {{cite journal | vauthors = Yamaguchi Y, Pasquale EB | title = Eph receptors in the adult brain. | journal = Curr. Opin. Neurobiol. | volume = 14 | issue = 3 | pages = 288–96 | year = 2004 | pmid = 15194108 | doi = 10.1016/j.conb.2004.04.003 | s2cid = 26196696 }}
• {{cite journal | vauthors = Murai KK, Pasquale EB | title = Eph receptors, ephrins, and synaptic function. | journal = The Neuroscientist | volume = 10 | issue = 4 | pages = 304–14 | year = 2004 | pmid = 15271258 | doi = 10.1177/1073858403262221 | s2cid = 23900846 }}
• {{cite journal | vauthors = Park S, Sánchez MP | title = The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. | journal = Oncogene | volume = 14 | issue = 5 | pages = 533–42 | year = 1997 | pmid = 9053851 | doi = 10.1038/sj.onc.1200857 | s2cid = 21779523 | doi-access = }}
• {{cite journal | vauthors = Park S, Frisén J, Barbacid M | title = Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. | journal = EMBO J. | volume = 16 | issue = 11 | pages = 3106–14 | year = 1997 | pmid = 9214628 | pmc = 1169929 | doi = 10.1093/emboj/16.11.3106 }}
• {{cite journal | vauthors = Ephnomenclaturecommittee | title = Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. | journal = Cell | volume = 90 | issue = 3 | pages = 403–4 | year = 1997 | pmid = 9267020 | doi = 10.1016/S0092-8674(00)80500-0 | s2cid = 26773768 | doi-access = free }}
• {{cite journal | vauthors = Lemke G | title = A coherent nomenclature for Eph receptors and their ligands. | journal = Mol. Cell. Neurosci. | volume = 9 | issue = 5–6 | pages = 331–2 | year = 1998 | pmid = 9361271 | doi = 10.1006/mcne.1997.0630 | s2cid = 6608696 }}
• {{cite journal | vauthors = Choi S, Park S | title = Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. | journal = Oncogene | volume = 18 | issue = 39 | pages = 5413–22 | year = 1999 | pmid = 10498895 | doi = 10.1038/sj.onc.1202917 | s2cid = 11001580 | doi-access = }}

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Category:Tyrosine kinase receptors

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