EPM

• École Polytechnique de Montréal, now Polytechnique Montréal, an engineering school in Canada
• Escola Portuguesa de Moçambique, a Portuguese school in Maputo, Mozambique
• Macau Portuguese School (Portuguese: {{lang|pt|Escola Portuguesa de Macau}})

• Enterprise performance management
• Enterprise project management

• "E. P. M. (Extreme Power Metal)", a song by DragonForce from their 2008 album Ultra Beatdown
• Extreme Power Metal, a 2019 album by DragonForce
• EPM Musique, a French record label

• Electronic protective measures
• Electropermanent magnet
• Electropositive metal, in electropositive shark repellent
• Elevated plus maze, a rodent-based model of anxiety
• Equine protozoal myeloencephalitis
• Ethylene propylene rubber
• European Physiology Modules, an International Space Station payload
• Evolved psychological mechanism
• Expanding photosphere method

• EPM (cycling team), a Colombian cycling team
• Eastport Municipal Airport, in Maine, United States
• Empresas Públicas de Medellín, a Colombian public utility
• An Enquiry Concerning the Principles of Morals, a 1751 book by Scottish philosopher David Hume
• Epsom railway station, Victoria
• European Peace Marches
• Macau Prison (Portuguese: {{lang|pt|Estabelecimento Prisional de Macau}})
• Pyrenees–Mediterranean Euroregion (French: {{lang|fr|Eurorégion Pyrénées–Méditerannée}})

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