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EPN2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Epsin-2 is a protein that in humans is encoded by the EPN2 gene.{{cite journal | vauthors = Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P | title = The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module | journal = J Biol Chem | volume = 274 | issue = 48 | pages = 33959–65 |date=Dec 1999 | pmid = 10567358 | doi =10.1074/jbc.274.48.33959 | doi-access = free }}{{cite web | title = Entrez Gene: EPN2 epsin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22905}}

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

References

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Further reading

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  • {{cite journal | vauthors=Salcini AE, Confalonieri S, Doria M |title=Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module |journal=Genes Dev. |volume=11 |issue= 17 |pages= 2239–49 |year= 1997 |pmid= 9303539 |doi=10.1101/gad.11.17.2239 | pmc=275390 |display-authors=etal}}
  • {{cite journal | vauthors=Yamabhai M, Hoffman NG, Hardison NL |title=Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains |journal=J. Biol. Chem. |volume=273 |issue= 47 |pages= 31401–7 |year= 1998 |pmid= 9813051 |doi=10.1074/jbc.273.47.31401 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Kikuno R, Nagase T, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ford MG, Mills IG, Peter BJ |title=Curvature of clathrin-coated pits driven by epsin |journal=Nature |volume=419 |issue= 6905 |pages= 361–6 |year= 2002 |pmid= 12353027 |doi= 10.1038/nature01020 |bibcode=2002Natur.419..361F |s2cid=4372368 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Hussain NK, Yamabhai M, Bhakar AL |title=A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28823–30 |year= 2003 |pmid= 12750376 |doi= 10.1074/jbc.M300995200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Colland F, Jacq X, Trouplin V |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}}
  • {{cite journal | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |display-authors=etal|doi-access=free |bibcode=2004CBio...14.1436J }}
  • {{cite journal | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
  • {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}

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