ERG11

{{Infobox nonhuman protein

| Name = Sterol 14-demethylase

| image =

| width =

| caption =

| Organism = Saccharomyces cerevisiae

| TaxID = 4932

| Symbol = ERG11

| AltSymbols = CYP51F1

| EntrezGene = 856398

| HomoloGene = 55488

| PDB =

| RefSeqmRNA = NM_001179137

| RefSeqProtein = NP_011871

| UniProt = P10614

| ECnumber = 1.14.14.154

| Chromosome = VIII

| EntrezChromosome = NC_001140

| GenLoc_start = 120091

| GenLoc_end = 121683

}}

ERG11 or sterol 14-demethylase is a fungal cytochrome P450 enzyme originally from Saccharomyces cerevisiae, belongs to family CYP51, with the CYP Symbol CYP51F1.{{cite journal | vauthors = Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS | display-authors = 6 | title = Global analysis of protein expression in yeast | journal = Nature | volume = 425 | issue = 6959 | pages = 737–41 | date = October 2003 | pmid = 14562106 | doi = 10.1038/nature02046 | bibcode = 2003Natur.425..737G | s2cid = 4344864 }} ERG11 catalyzes the C14-demethylation of lanosterol to 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol which is the first step of biosynthesis of the zymosterol, zymosterol will be further converted into ergosterol.{{cite journal | vauthors = Mo C, Bard M | title = Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex | journal = Journal of Lipid Research | volume = 46 | issue = 9 | pages = 1991–8 | date = September 2005 | pmid = 15995173 | doi = 10.1194/jlr.M500153-JLR200 | doi-access = free }}