ETR

• ElettroTreno, a series of Italian high-speed trains
• Echigo Tokimeki Railway, a railway operating company in Japan
• Santa Rosa International Airport, serving Machala, Ecuador
• Essex Terminal Railway, a short line railroad in Canada

• Second East Turkestan Republic
• Edolo language; ISO language code
• Entergy Corporation; NYSE stock symbol
• Etravirine, a drug used to suppress HIV replication
• Existential theory of the reals, formal language in computer science
• Express Toll Route, in Canada; Ontario Highway 407

• Xetra (trading system); XETR
• Eastern Test Range, a rocket testing area off of Cape Canaveral; ER or AFETR

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