EXOC3L2
Exocyst complex component 3-like 2 is a protein that in humans is encoded by the EXOC3L2 gene.{{cite journal |pmid=21566143 |year=2011 |last1=Barkefors |first1=I |last2=Fuchs |first2=PF |last3=Heldin |first3=J |last4=Bergström |first4=T |last5=Forsberg-Nilsson |first5=K |last6=Kreuger |first6=J |title=Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells |volume=286 |issue=27 |pages=24189–99 |doi=10.1074/jbc.M110.212209 |pmc=3129200 |journal=The Journal of Biological Chemistry|doi-access=free }}{{EntrezGene|90332}}{{cite journal |pmid=22191060 |year=2011 |last1=Olgiati |first1=P |last2=Politis |first2=AM |last3=Papadimitriou |first3=GN |last4=De Ronchi |first4=D |last5=Serretti |first5=A |title=Genetics of late-onset Alzheimer's disease: Update from the alzgene database and analysis of shared pathways |volume=2011 |pages=832379 |doi=10.4061/2011/832379 |pmc=3235576 |journal=International Journal of Alzheimer's Disease |doi-access=free }}{{cite journal |pmid=21132329 |year=2011 |last1=Belbin |first1=O |last2=Carrasquillo |first2=MM |last3=Crump |first3=M |last4=Culley |first4=OJ |last5=Hunter |first5=TA |last6=Ma |first6=L |last7=Bisceglio |first7=G |last8=Zou |first8=F |last9=Allen |first9=M |title=Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease |volume=129 |issue=3 |pages=273–82 |doi=10.1007/s00439-010-0924-2 |pmc=3036835 |journal=Human Genetics }}
The EXOC3L2 protein has been shown to interact with EXOC4 that is a component of the exocyst complex{{cite journal |pmid=21997494 |year=2011 |last1=Liu |first1=J |last2=Guo |first2=W |title=The exocyst complex in exocytosis and cell migration |doi=10.1007/s00709-011-0330-1 |journal=Protoplasma|volume=249 |issue=3 |pages=587–597 |s2cid=11946932 }}{{cite journal |pmid=16826234 |year=2006 |last1=Munson |first1=M |last2=Novick |first2=P |title=The exocyst defrocked, a framework of rods revealed |volume=13 |issue=7 |pages=577–81 |doi=10.1038/nsmb1097 |journal=Nature Structural & Molecular Biology|s2cid=26645238 }} involved exocytosis and more specifically in the targeting of exocytic vesicles to the cell membrane.
The exocyst complex is important for several biological processes, such as the establishment of cell polarity and regulation of cell migration.{{cite journal |pmid=22264730 |year=2012 |last1=Thapa |first1=N |last2=Sun |first2=Y |last3=Schramp |first3=M |last4=Choi |first4=S |last5=Ling |first5=K |last6=Anderson |first6=RA |title=Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells |volume=22 |issue=1 |pages=116–30 |doi=10.1016/j.devcel.2011.10.030 |pmc=3266520 |journal=Developmental Cell}} The structure and functions of the exocyst complex are conserved from yeast to higher eukaryotes. Endothelial cells in blood vessels express high levels of EXOC3L2 that is required for proper VEGFR-2 signaling so that the endothelial cells can migrate towards the growth factor VEGF-A.{{cite journal |pmid=21593862 |year=2011 |last1=Carmeliet |first1=P |last2=Jain |first2=RK |title=Molecular mechanisms and clinical applications of angiogenesis |volume=473 |issue=7347 |pages=298–307 |doi=10.1038/nature10144 |journal=Nature|pmc=4049445 |bibcode=2011Natur.473..298C }}