Early versus Late Intervention Trial with Estradiol

The Early versus Late Intervention Trial with Estradiol (ELITE) was a large randomized controlled trial that assessed the timing hypothesis that menopausal hormone therapy in early but not late menopause would improve cardiovascular outcomes.{{cite journal | vauthors = Hodis HN, Mack WJ, Shoupe D, Azen SP, Stanczyk FZ, Hwang-Levine J, Budoff MJ, Henderson VW | title = Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis | journal = Menopause | volume = 22 | issue = 4 | pages = 391–401 | date = April 2015 | pmid = 25380275 | pmc = 4376597 | doi = 10.1097/GME.0000000000000343 }}{{cite journal | vauthors = Pabbidi MR, Kuppusamy M, Didion SP, Sanapureddy P, Reed JT, Sontakke SP | title = Sex differences in the vascular function and related mechanisms: role of 17β-estradiol | journal = Am. J. Physiol. Heart Circ. Physiol. | volume = 315 | issue = 6 | pages = H1499–H1518 | date = December 2018 | pmid = 30192631 | doi = 10.1152/ajpheart.00194.2018 | doi-access = free }}