Edestin

{{Short description|Globular protein from Hemp}}

Edestin, (also known as Edistin{{cite journal |vauthors=Möller G, Fernandez C|title=Immunological tolerance to the thymus-independent antigen dextran can be abrogated by thymus-dependent dextran conjugates: evidence against clonal deletion as the mechanism of tolerance induction |journal=Scandinavian Journal of Immunology |volume=8 |issue=1 |pages=29–37 |year=1978 |pmid=309173 |doi=10.1111/j.1365-3083.1978.tb00493.x|s2cid=40616995 }}) is a highly-digestible, hexameric legumin protein with six subunits, {{Cite journal |last1=Patel |first1=Samit |last2=Cudney |first2=Robert |last3=McPherson |first3=Alexander |date=1994-01-07 |title=Crystallographic characterization and molecular symmetry of edestin, a legumin from hemp |url=https://www.sciencedirect.com/science/article/pii/S0022283605800403 |journal=Journal of Molecular Biology |language=en |volume=235 |issue=1 |pages=361–363 |doi=10.1016/S0022-2836(05)80040-3 |pmid=8289257 |s2cid=30690679 |issn=0022-2836}}{{cite journal |pmid = 8289257 | doi=10.1016/S0022-2836(05)80040-3 | volume=235 | issue=1 | title=Crystallographic characterization and molecular symmetry of edestin, a legumin from hemp |date=January 1994 | journal=J. Mol. Biol. | pages=361–3 |vauthors=Patel S, Cudney R, McPherson A| s2cid=30690679 | url=http://www.escholarship.org/uc/item/5m39g85p }}{{cite journal |author=Chuan-He Tang |title=Physicochemical and functional properties of hemp (Cannabis sativa L.) protein isolate |journal=J Agric Food Chem |pages=8945–8950 |date=November 15, 2006 |pmid=17090145 |doi=10.1021/jf0619176 |volume=54|issue=23 }} and a seed storage protein,{{cite journal |author=Teresa Docimo |title=Molecular characterization of edestin gene family in Cannabis sativa L |journal=Plant Physiology and Biochemistry |volume=84 |pages=142–148 |date=September 24, 2014 |pmid=25280223 |doi=10.1016/j.plaphy.2014.09.011}} with a molecular weight of 310 kDa.{{Cite web|url=https://www.britannica.com/science/protein/Proteins-of-the-blood-serum#ref593830|title = Protein - Proteins of the blood serum | Britannica}} This protein is primarily found in hemp seeds. Edestin is a globular protein (biologically active) as opposed to fibrous protein (structural).

Globular proteins found in edestin (and in Alpha 1 globulins, Alpha 2 globulins, Beta globulins, and Gamma globulins) are long peptide chains, precursors for biological proteins essential for life. Edestin is similar to serum globulin (blood plasma), and the biologically active protein of edestin is metabolized in the human body and capable of biosynthesizing:{{cite journal |author=Tombs MP |title=A haemoglobin-binding beta-globulin in human serum |journal=Nature |volume=186 |issue= 4730|pages=1055–6 |year=1960 |pmid=13838734 |doi=10.1038/1861055b0|bibcode=1960Natur.186.1055T |s2cid=4213851 }}

• hormones (which regulate all the body processes),
• hemoglobin (which transports oxygen, carbon dioxide, and nitric oxide),
• enzymes (which catalyze and control biochemical reactions),
• antibodies (immunoglobulins which fend off invading bacteria, viruses, and other pathogens, as well as toxins or antigens as they enter the body).

Edestin can also be broken down to edestan.{{cite journal |author=Kenneth Bailey |title=The denaturation of edestin by acid: T. B. Osborne's edestan |journal=Biochemical Journal |pages=140–154 |date=January 29, 1942 |pmc=1265671 |pmid=16747476 |volume=36 |issue=1–2 |doi=10.1042/bj0360140}}