EggNOG (database)

{{infobox biodatabase

|title = eggNOG

|logo =File:Database.png

|description = Database of orthologous proteins and functional annotations at multiple taxonomical levels.

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|center = European Molecular Biology Laboratory

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|author = Huerta-Cepas et al.

|citation = Huerta-Cepas et al. (2015)

|released = 2015

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|url = http://eggnogdb.embl.de

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}}The eggNOG database is a database of biological information hosted by the EMBL. It is based on the original idea of COGs (clusters of orthologous groups){{cite journal |vauthors=Tatusov RL, Koonin EV, Lipman DJ |title=A genomic perspective on protein families |journal=Science |volume=278 |issue=5338 |pages=631–7 |year=1997 |pmid=9381173 |doi=10.1126/science.278.5338.631 |bibcode=1997Sci...278..631T |url=https://zenodo.org/record/1231126}}{{cite journal |vauthors=Tatusov RL, Galperin MY, Natale DA, Koonin EV |title=The COG database: a tool for genome-scale analysis of protein functions and evolution |journal=Nucleic Acids Res. |volume=28 |issue=1 |pages=33–6 |year=2000 |pmid=10592175 |pmc=102395 |doi=10.1093/nar/28.1.33 }} and expands that idea to non-supervised orthologous groups constructed from numerous organisms.{{cite journal |last=Powell |first=Sean |author2=Szklarczyk, Damian |author3=Trachana, Kalliopi |author4=Roth, Alexander |author5=Kuhn, Michael |author6=Muller, Jean |author7=Arnold, Roland |author8=Rattei, Thomas |author9=Letunic, Ivica |author10=Doerks, Tobias |author11=Jensen, Lars J |author12=von Mering, Christian |author13=Bork, Peer |date=January 2012 |title=eggNOG v3.0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges |journal=Nucleic Acids Research |volume=40 |issue=D1 |pages=D284–D289 |pmid=22096231 |doi=10.1093/nar/gkr1060 |pmc=3245133}} The database was created in 2007{{cite journal |vauthors=Jensen LJ, Julien P, Kuhn M, von Mering C, Muller J, Doerks T, Bork P |title=eggNOG: automated construction and annotation of orthologous groups of genes |journal=Nucleic Acids Res. |volume=36 |issue=Database issue |pages=D250–4 |year=2008 |pmid=17942413 |pmc=2238944 |doi=10.1093/nar/gkm796 }} and updated to version 4.5 in 2015.{{cite journal |vauthors=Huerta-Cepas J, Szklarczyk D, Forslund K, Cook H, Heller D, Walter MC, Rattei T, Mende DR, Sunagawa S, Kuhn M, Jensen LJ, von Mering C, Bork P |title=eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences |journal=Nucleic Acids Res. |volume=44 |issue=D1 |pages=D286–93 |year=2016 |pmid=26582926 |pmc=4702882 |doi=10.1093/nar/gkv1248 }} eggNOG stands for evolutionary genealogy of genes: Non-supervised Orthologous Groups.