Elaine Holmes

Holmes received a BSc in biology from Goldsmiths College, University of London, and a PhD in analytical chemistry from Birkbeck College, at the University of London.{{Cite web |title=Research Gate |url=https://www.researchgate.net/profile/Elaine-Holmes}} She was the first person in her family to attend university.{{Cite web |last=White |first=Merran |date=2020-09-24 |title=Meet Dr Elaine Holmes: Microbiome-diet expert |url=https://www.futurefoodsystems.com.au/meet-dr-elaine-holmes-microbiome-diet-expert/ |access-date=2024-06-22 |website=Future Food Systems |language=en-AU}} At Imperial College, Holmes was head of department of the Division of Computational and Systems Medicine, as well as a professor of chemical biology, located within the Department of Surgery and Cancer.{{Cite web |title=Imperial UK |url=https://profiles.imperial.ac.uk/elaine.holmes |access-date=2024-06-22 |website=profiles.imperial.ac.uk}} She was a professor of Computational Science at Murdoch University in 2024.{{Cite web |date=2021-10-26 |title=Our people - Perron Institute |url=https://www.perroninstitute.org/about-us/our-people/ |access-date=2024-06-22 |website=www.perroninstitute.org |language=en-AU}}

Holmes is the Director of the Centre for Computational & Systems medicine, and Director and co-founder of [https://find-and-update.company-information.service.gov.uk/company/10572078 Melico Sciences Limited], a UK-based precision nutrition start-up, and director of [https://find-and-update.company-information.service.gov.uk/company/03982959 Metabometrix Limited], an Imperial College London spin-off company incorporated in April 2000 and specializing in molecular phenotyping, clinical diagnostics and toxicological screening via metabolomics.

Holmes was awarded a $3 million fellowship from the Australian Research Council for aging and biochemistry research. Her research involves gut microbial influences on human health, in particular, examining liver, metabolomic and gastrointestinal diseases. These diseases include diabetes and dementia.{{Cite web |title=ARC |url=https://www.arc.gov.au/funding-research/funding-schemes/discovery-program/australian-laureate-fellowships/2020-laureate-profile-professor-elaine-holmes.}}

Holmes is on the Editorial Boards of the Journal of Biological Chemistry, and Analytical Biochemistry. Her research has been described by the BBC, including impacts on the body from chamomile tea{{Cite web |title=BBC news |url=http://news.bbc.co.uk/2/hi/health/4183549.stm}} and how herbal mixtures can help impact gut microbiome health.{{Cite journal |last=Callaway |first=Ewen |date=2010-08-18 |title=How an 1,800-year-old herbal mix heals the gut |url=https://www.nature.com/articles/news.2010.417 |journal=Nature |language=en |doi=10.1038/news.2010.417 |issn=1476-4687|url-access=subscription }}

Holmes has over 92,000 citations, as at June 2024, according to Google Scholar.{{Cite web |title=Elaine Holmes |url=https://scholar.google.com/citations?user=WwyxgikAAAAJ&hl=en |access-date=2024-06-22 |website=scholar.google.com}} Her H-index is 147, and she has publications in Science,{{Cite journal |last1=Nicholson |first1=Jeremy K. |last2=Holmes |first2=Elaine |last3=Kinross |first3=James |last4=Burcelin |first4=Remy |last5=Gibson |first5=Glenn |last6=Jia |first6=Wei |last7=Pettersson |first7=Sven |date=2012-06-08 |title=Host-Gut Microbiota Metabolic Interactions |url=https://www.science.org/doi/10.1126/science.1223813 |journal=Science |language=en |volume=336 |issue=6086 |pages=1262–1267 |doi=10.1126/science.1223813 |pmid=22674330 |bibcode=2012Sci...336.1262N |issn=0036-8075|url-access=subscription }} Nature Reviews,{{Cite web |title=Metabonomics: a platform for studying drug toxicity and gene function |url=https://scholar.google.com/citations?view_op=view_citation&hl=en&user=WwyxgikAAAAJ&citation_for_view=WwyxgikAAAAJ:u-x6o8ySG0sC |access-date=2024-06-22 |website=scholar.google.com}} Nature Protocols, the Proceedings of the National Academy of Sciences,{{Cite journal |last1=Smith |first1=Michelle I. |last2=Yatsunenko |first2=Tanya |last3=Manary |first3=Mark J. |last4=Trehan |first4=Indi |last5=Mkakosya |first5=Rajhab |last6=Cheng |first6=Jiye |last7=Kau |first7=Andrew L. |last8=Rich |first8=Stephen S. |last9=Concannon |first9=Patrick |last10=Mychaleckyj |first10=Josyf C. |last11=Liu |first11=Jie |last12=Houpt |first12=Eric |last13=Li |first13=Jia V. |last14=Holmes |first14=Elaine |last15=Nicholson |first15=Jeremy |date=2013 |title=Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor |journal=Science |language=en |volume=339 |issue=6119 |pages=548–554 |doi=10.1126/science.1229000 |pmid=23363771 |issn=0036-8075|pmc=3667500 |bibcode=2013Sci...339..548S }} and Nature.{{Cite web |title=Human metabolic phenotype diversity and its association with diet and blood pressure |url=https://scholar.google.com/citations?view_op=view_citation&hl=en&user=WwyxgikAAAAJ&citation_for_view=WwyxgikAAAAJ:Tyk-4Ss8FVUC |access-date=2024-06-22 |website=scholar.google.com}} Holmes has also published with Fiona Woods, surgeon and burns specialist.{{Cite journal |last1=Ryan |first1=Monique J. |last2=Raby |first2=Edward |last3=Whiley |first3=Luke |last4=Masuda |first4=Reika |last5=Lodge |first5=Samantha |last6=Nitschke |first6=Philipp |last7=Maker |first7=Garth L. |last8=Wist |first8=Julien |last9=Holmes |first9=Elaine |last10=Wood |first10=Fiona M. |last11=Nicholson |first11=Jeremy K. |last12=Fear |first12=Mark W. |last13=Gray |first13=Nicola |date=2023-11-21 |title=Nonsevere Burn Induces a Prolonged Systemic Metabolic Phenotype Indicative of a Persistent Inflammatory Response Postinjury |journal=Journal of Proteome Research |volume=23 |issue=8 |pages=2893–2907 |language=en |doi=10.1021/acs.jproteome.3c00516 |pmid=38104259 |issn=1535-3893|pmc=11302432 }}

Select publications include:

• Ryan, Monique J et al. (2023) “Nonsevere Burn Induces a Prolonged Systemic Metabolic Phenotype Indicative of a Persistent Inflammatory Response Postinjury.” Journal of Proteome Research (2023).
• Nicholson, J. K., Lindon, J. C., & Holmes, E. (1999). “Metabonomics”: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica, 29(11), 1181–1189. https://doi.org/10.1080/004982599238047{{Cite web |title=Tandfonline | doi=10.1080/004982599238047 |url=https://www.tandfonline.com/doi/citedby/10.1080/004982599238047?scroll=top&needAccess=true}}
• Holmes, E., Loo, R., Stamler, J. et al. (2008) Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 453, 396–400. https://doi.org/10.1038/nature06882{{Cite journal |last1=Holmes |first1=Elaine |last2=Loo |first2=Ruey Leng |last3=Stamler |first3=Jeremiah |last4=Bictash |first4=Magda |last5=Yap |first5=Ivan K. S. |last6=Chan |first6=Queenie |last7=Ebbels |first7=Tim |last8=De Iorio |first8=Maria|author8-link=Maria De Iorio |last9=Brown |first9=Ian J. |last10=Veselkov |first10=Kirill A. |last11=Daviglus |first11=Martha L. |last12=Kesteloot |first12=Hugo |last13=Ueshima |first13=Hirotsugu |last14=Zhao |first14=Liancheng |last15=Nicholson |first15=Jeremy K. |date=2008 |title=Human metabolic phenotype diversity and its association with diet and blood pressure |journal=Nature |language=en |volume=453 |issue=7193 |pages=396–400 |doi=10.1038/nature06882 |pmid=18425110 |issn=1476-4687|pmc=6556779 |bibcode=2008Natur.453..396H }}

• 2023 – Fellow of the Australian Academy of Sciences
• 2020 – ARC Laureate Fellow.
• 2020 – Women in Tech awards.{{Cite web |title=WITWA |url=https://www.witwa.org.au/initiatives/role-model/elaine-holmes/ |access-date=2024-06-22 |website=www.witwa.org.au/ |language=en-AU}}
• 2018 – Fellow of the Academy of Medical Sciences.{{Cite web |date=2018-05-10 |title=Top award for Imperial Surgery & Cancer Professor {{!}} Imperial News {{!}} Imperial College London |url=https://www.imperial.ac.uk/news/186255/top-award-imperial-surgery-cancer-professor/ |access-date=2024-06-22 |website=Imperial News |language=en}}
• 2018 – WA Premier's Fellow in Phenomics.
• 2018 – Royal Society for Chemistry medal.

{{Reflist}}

• Murdoch University [http://profiles.murdoch.edu.au/myprofile/elaine-holmes/]
• Australian Research Council [https://www.arc.gov.au/news-publications/media/funding-announcement-kits/australian-laureate-fellowships-2020/2020-laureate-profile-professor-elaine-holmes]
• Australian Academy of Sciences [https://www.science.org.au/profile/elaine-holmes]

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Category:Living people

Category:21st-century Australian biologists

Category:21st-century Australian women scientists

Category:Alumni of the University of London

Category:Academic staff of Murdoch University

Category:Fellows of the Australian Academy of Science

Category:21st-century Australian chemists

Category:Australian molecular biologists

Category:Year of birth missing (living people)