Elizabeth Harry
{{short description|Australian biologist}}
{{Use dmy dates|date=April 2018}}
{{Use Australian English|date=April 2018}}
{{BLP sources|date=August 2014}}
Elizabeth "Liz" Harry is Professor of Biology and Director of the ithree institute (infection, immunology and innovation) at the University of Technology, Sydney, Australia (UTS).
Career
Harry obtained her PhD in Biochemistry from the University of Sydney before attending Harvard University as a National Institutes of Health Postdoctoral Fellow where she pioneered the development of fluorescence microscopy techniques for bacteria that enabled visualisation of the subcellular proteins inside bacterial cells.{{Citation needed|date=November 2022}} and revealed that the proteins within bacterial cells have specific cellular addresses.{{Citation needed|date=November 2022}}
She then returned to Australia to be an Australian Research Council Postdoctoral then QEII Fellow at the University of Sydney. She then became Associate Professor at the Institute for the Biotechnology of Infectious Diseases at UTS before being promoted to Professor of Biology in 2010.{{Citation needed|date=November 2022}}
Achievements
Harry's research on bacterial cell division has had a significant impact on our understanding of how bacterial cells multiply, and how they control this process to ensure equal partitioning of chromosomes vital for survival. Her research has often changed the direction of thinking in the field, and has afforded excellent opportunities in antibacterial discovery. Her cutting-edge cell biology techniques including super resolution microscopy have provided unique insights in the mechanism and spatiotemporal control of the division process in bacteria. She discovered that the cytokinetic ring, which is a polymer of the tubulin-like protein, FtsZ, forms at the division site at midcell as a result of the remodelling of a cytoskeletal helical assembly of polymers.{{Cite journal |last1=Strauss |first1=Michael P. |last2=Liew |first2=Andrew T. F. |last3=Turnbull |first3=Lynne |last4=Whitchurch |first4=Cynthia B. |last5=Monahan |first5=Leigh G. |last6=Harry |first6=Elizabeth J. |date=2012-09-11 |editor-last=Amos |editor-first=Linda |title=3D-SIM Super Resolution Microscopy Reveals a Bead-Like Arrangement for FtsZ and the Division Machinery: Implications for Triggering Cytokinesis |journal=PLOS Biology |language=en |volume=10 |issue=9 |pages=e1001389 |doi=10.1371/journal.pbio.1001389 |issn=1545-7885 |pmc=3439403 |pmid=22984350 |doi-access=free }} Her research has shown that this Z ring is linked to the progress of the initiation phase of DNA replication, and gave rise to a new definition for the role of long-known spatial regulators of bacterial division.{{Citation needed|date=November 2022}}
More recently{{When|date=November 2022}} Harry has been researching antibacterial discovery and bacterial cell division of bacteria that cause infectious disease,{{Cite journal |last1=Robinson |first1=Andrew |last2=Brzoska |first2=Anthony J. |last3=Turner |first3=Kylie M. |last4=Withers |first4=Ryan |last5=Harry |first5=Elizabeth J. |last6=Lewis |first6=Peter J. |last7=Dixon |first7=Nicholas E. |date=June 2010 |title=Essential Biological Processes of an Emerging Pathogen: DNA Replication, Transcription, and Cell Division in Acinetobacter spp |journal=Microbiology and Molecular Biology Reviews |language=en |volume=74 |issue=2 |pages=273–297 |doi=10.1128/MMBR.00048-09 |issn=1092-2172 |pmc=2884411 |pmid=20508250}} and has worked with industry on the development of novel antibiotics that target this process in pathogens.{{Citation needed|date=November 2022}}
Awards
Harry was awarded the 2002 Australian Eureka Prize for Scientific Research,{{cite web|title=Associate Professor Liz Harry|url=http://www.abc.net.au/catalyst/stories/2668977.htm|website=Catalyst|publisher=Australian Broadcasting Corporation|accessdate=15 August 2014|date=27 August 2009|url-status=live|archiveurl=https://web.archive.org/web/20140820140822/http://www.abc.net.au/catalyst/stories/2668977.htm|archivedate=20 August 2014|df=dmy-all}} and the 2008 Frank Fenner Award by the Australian Society for Microbiology in recognition of her contributions to Australian research in microbiology.{{Citation needed|date=November 2022}} She has had several plenary invitations to international conferences and served on the executive of the Australian Society for Microbiology for several years. She is currently a member of the Australian Academy of Science, National Committee for Biomedical Sciences.{{Cite web|url=http://www.uts.edu.au/staff/elizabeth.harry|title=Liz Harry {{!}} University of Technology Sydney|website=www.uts.edu.au|language=en|archive-url=https://web.archive.org/web/20140814080749/http://www.uts.edu.au/staff/elizabeth.harry|archive-date=14 August 2014|url-status=live|df=dmy-all}}
Selected publications
- {{Cite journal |last1=Blair |first1=S. E. |last2=Cokcetin |first2=N. N. |last3=Harry |first3=E. J. |last4=Carter |first4=D. A. |date=October 2009 |title=The unusual antibacterial activity of medical-grade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis |url=http://link.springer.com/10.1007/s10096-009-0763-z |journal=European Journal of Clinical Microbiology & Infectious Diseases |language=en |volume=28 |issue=10 |pages=1199–1208 |doi=10.1007/s10096-009-0763-z |pmid=19513768 |s2cid=10947814 |issn=0934-9723|url-access=subscription }}
- {{Cite journal |last1=Lock |first1=Rowena L. |last2=Harry |first2=Elizabeth J. |date=April 2008 |title=Cell-division inhibitors: new insights for future antibiotics |url=https://www.nature.com/articles/nrd2510 |journal=Nature Reviews Drug Discovery |language=en |volume=7 |issue=4 |pages=324–338 |doi=10.1038/nrd2510 |pmid=18323848 |s2cid=6846383 |issn=1474-1784|url-access=subscription }}
- {{Cite journal |last1=Liu |first1=Sanly |last2=Gunawan |first2=Cindy |last3=Barraud |first3=Nicolas |last4=Rice |first4=Scott A. |last5=Harry |first5=Elizabeth J. |last6=Amal |first6=Rose |date=2016-09-06 |title=Understanding, Monitoring, and Controlling Biofilm Growth in Drinking Water Distribution Systems |url=https://pubs.acs.org/doi/10.1021/acs.est.6b00835 |journal=Environmental Science & Technology |language=en |volume=50 |issue=17 |pages=8954–8976 |doi=10.1021/acs.est.6b00835 |pmid=27479445 |bibcode=2016EnST...50.8954L |hdl=10453/49239 |issn=0013-936X|hdl-access=free }}
- {{Cite journal |last1=Strauss |first1=Michael P. |last2=Liew |first2=Andrew T. F. |last3=Turnbull |first3=Lynne |last4=Whitchurch |first4=Cynthia B. |last5=Monahan |first5=Leigh G. |last6=Harry |first6=Elizabeth J. |date=2012-09-11 |editor-last=Amos |editor-first=Linda |title=3D-SIM Super Resolution Microscopy Reveals a Bead-Like Arrangement for FtsZ and the Division Machinery: Implications for Triggering Cytokinesis |journal=PLOS Biology |language=en |volume=10 |issue=9 |pages=e1001389 |doi=10.1371/journal.pbio.1001389 |issn=1545-7885 |pmc=3439403 |pmid=22984350 |doi-access=free }}
- {{Citation |last1=Harry |first1=Elizabeth |title=Bacterial Cell Division: The Mechanism and Its Precison |date=2006-01-01 |url=https://www.sciencedirect.com/science/article/pii/S0074769606530025 |volume=253 |pages=27–94 |publisher=Academic Press |language=en |doi=10.1016/s0074-7696(06)53002-5 |access-date=2022-11-01 |last2=Monahan |first2=Leigh |last3=Thompson |first3=Lyndal|series=International Review of Cytology |pmid=17098054 |isbn=9780123735973 |url-access=subscription }}
- {{Cite journal |last1=Carter |first1=Dee A. |last2=Blair |first2=Shona E. |last3=Cokcetin |first3=Nural N. |last4=Bouzo |first4=Daniel |last5=Brooks |first5=Peter |last6=Schothauer |first6=Ralf |last7=Harry |first7=Elizabeth J. |date=2016 |title=Therapeutic Manuka Honey: No Longer So Alternative |journal=Frontiers in Microbiology |volume=7 |page=569 |doi=10.3389/fmicb.2016.00569 |issn=1664-302X |pmc=4837971 |pmid=27148246|doi-access=free }}
References
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Category:Australian biochemists
Category:Australian microbiologists
Category:Australian women microbiologists
Category:Australian women chemists
Category:Academic staff of the University of Technology Sydney