Endometrioid tumor

File:Incidence of ovarian cancers by histopathology.png.{{Cite book|contribution=Chapter 16: Cancers of the Ovary|first=Carol L.|last=Kosary|pages=133–144|publisher=National Cancer Institute|title=SEER Survival Monograph: Cancer Survival Among Adults: US SEER Program, 1988-2001, Patient and Tumor Characteristics|editor1-last=Baguio|editor1-first=RNL|editor2-last=Young|editor2-first=JL|editor3-last=Keel|editor3-first=GE|editor4-last=Eisner|editor4-first=MP|editor5-last=Lin|editor5-first=YD|editor6-last=Horner|editor6-first=M-J|series=SEER Program|volume=NIH Pub. No. 07-6215|place=Bethesda, MD|year=2007|chapter-url=http://seer.cancer.gov/publications/survival/surv_ovary.pdf|url=http://seer.cancer.gov/publications/survival/}} Endometrioid tumor is labeled at bottom left.]]

Ovarian endometrioid tumors are part of the surface epithelial tumor group of ovarian neoplasms (10–20% of which are the endometrioid type).

Benign and borderline variants are rare, as the majority are malignant.

There is an association with endometriosis and concurrent primary endometrial carcinoma (endometrial cancer).

On gross pathological examination, the tumor is cystic and may be solid and some arise in cystic endometriosis. In 40% of cases, endometrioid tumors are found bilaterally.{{cite book |editor1-last=Robbins |editor2-last=Cotran |title=Pathologic Basis of Disease |location=Philadelphia |publisher=Saunders |edition=7th |isbn=978-0-7216-0187-8 |year=2005 }}

Endometrioid carcinoma can also arise in the endometrium.{{cite journal |vauthors=Mulvany NJ, Allen DG |title=Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium |journal=Int. J. Gynecol. Pathol. |volume=27 |issue=1 |pages=49–57 |date=January 2008 |pmid=18156975 |doi=10.1097/pgp.0b013e31806219c5 |s2cid=43849133 }}{{MeshName|Carcinoma,+Endometrioid}}

Grades 1 and 2 are considered "type 1" endometrial cancer, while grade 3 is considered "type 2".{{cite web |url=http://www.cancer.org/docroot/cri/content/cri_2_4_1x_what_is_endometrial_cancer.asp |title=ACS :: What Is Endometrial Cancer? |access-date=2010-03-24 |archive-date=2010-06-20 |archive-url=https://web.archive.org/web/20100620010337/http://www.cancer.org/docroot/cri/content/cri_2_4_1x_what_is_endometrial_cancer.asp |url-status=dead }}

File:Pie chart of relative incidences of endometrial carcinoma.png|Relative incidences of endometrial carcinomas by histopathology, being endometrioid in a majority of cases{{cite journal|last1=Mendivil|first1=Alberto|last2=Schuler|first2=Kevin M.|last3=Gehrig|first3=Paola A.|title=Non-Endometrioid Adenocarcinoma of the Uterine Corpus: A Review of Selected Histological Subtypes|journal=Cancer Control|volume=16|issue=1|year=2009|pages=46–52|issn=1073-2748|doi=10.1177/107327480901600107|pmid=19078929}}

Light microscopy shows tubular glands, resembling endometrium.{{cite web|url=https://www.pathologyoutlines.com/topic/ovarytumorendometrioid.html|title=Ovary tumor - Endometrioid tumors - General|author-first1=Shahrzad|author-last1=Ehdaivand|website=Pathology Outlines|access-date=2020-03-17|archive-date=2020-02-16|archive-url=https://web.archive.org/web/20200216103323/http://www.pathologyoutlines.com/topic/ovarytumorendometrioid.html|url-status=dead}} Topic Completed: 1 December 2012. Revised: 6 March 2020

Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN gene mutation profiles. PTEN mutations are more frequent in low-grade endometrial endometrioid carcinomas (67%) compared with low-grade ovarian endometrioid carcinomas (17%). By contrast, CTNNB1 mutations are significantly different in low-grade ovarian endometrioid carcinomas (53%) compared with low-grade endometrial endometrioid carcinomas (28%). This difference in CTNNB1 mutation frequency may be reflective of the distinct tumoral microenvironments; the epithelial cells lining an endometriotic cyst within the ovary are exposed to a highly oxidative environment that promotes tumorigenesis.{{Cite journal | pmid = 23765252| year = 2014| last1 = McConechy| first1 = M. K.| title = Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles| journal = Modern Pathology| volume = 27| issue = 1| pages = 128–34| last2 = Ding| first2 = J| last3 = Senz| first3 = J| last4 = Yang| first4 = W| last5 = Melnyk| first5 = N| last6 = Tone| first6 = A. A.| last7 = Prentice| first7 = L. M.| last8 = Wiegand| first8 = K. C.| last9 = McAlpine| first9 = J. N.| last10 = Shah| first10 = S. P.| last11 = Lee| first11 = C. H.| last12 = Goodfellow| first12 = P. J.| last13 = Gilks| first13 = C. B.| last14 = Huntsman| first14 = D. G.| doi = 10.1038/modpathol.2013.107| pmc = 3915240}}

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{{Tumor histology}}

{{Breast cancer/urogenital neoplasia}}

{{DEFAULTSORT:Endometrioid Tumor}}

Category:Gynaecological cancer