Enkephalinase

Enkephalinases are enzymes that degrade endogenous enkephalin opioid peptides. They include:

• Aminopeptidase N (APN){{cite journal | vauthors = Thanawala V, Kadam VJ, Ghosh R | title = Enkephalinase inhibitors: potential agents for the management of pain | journal = Current Drug Targets | volume = 9 | issue = 10 | pages = 887–94 | date = October 2008 | pmid = 18855623 | doi = 10.2174/138945008785909356 | url = http://www.bentham-direct.org/pages/content.php?CDT/2008/00000009/00000010/0009J.SGM | archive-url = https://archive.today/20130414094722/http://www.bentham-direct.org/pages/content.php?CDT/2008/00000009/00000010/0009J.SGM | url-status = usurped | archive-date = 2013-04-14 | url-access = subscription }}
• Neutral endopeptidase (NEP)
• Dipeptidyl peptidase 3 (DPP3)
• Carboxypeptidase A6 (CPA6){{cite journal |vauthors=Lyons PJ, Callaway MB, Fricker LD | title = Characterization of carboxypeptidase A6, an extracellular matrix peptidase | journal = The Journal of Biological Chemistry | volume = 283 | issue = 11 | pages = 7054–63 |date=March 2008 | pmid = 18178555 | doi = 10.1074/jbc.M707680200 | doi-access = free }}
• Leucyl/cystinyl aminopeptidase (LNPEP)
• Angiotensin-converting enzyme (ACE){{cite journal |vauthors=Benuck M, Berg MJ, Marks N | title = Separate metabolic pathways for Leu-enkephalin and Met-enkephalin-Arg(6)-Phe(7) degradation by rat striatal synaptosomal membranes | journal = Neurochemistry International | volume = 4 | issue = 5 | pages = 389–96 | year = 1982 | pmid = 20487892 | doi = 10.1016/0197-0186(82)90081-X| s2cid = 23138078 }}