Enterovirus 5′ cloverleaf cis-acting replication element

{{Infobox rfam

| Name = Enterovirus 5′ cloverleaf cis-acting replication element

| image = RF00386.jpg

| width =

| caption = Predicted secondary structure and sequence conservation of Entero_5_CRE

| Symbol = Entero_5_CRE

| AltSymbols =

| Rfam = RF00386

| miRBase =

| miRBase_family =

| RNA_type = Cis-reg

| Tax_domain = Viruses

| GO =

| SO = {{SO|0000233}}

| CAS_number =

| EntrezGene =

| HGNCid =

| OMIM =

| PDB =

| RefSeq =

| Chromosome =

| Arm =

| Band =

| LocusSupplementaryData =

}}

The Enterovirus 5′ cloverleaf cis-acting replication element is an RNA element found in the 5′ UTR of Enterovirus genomes. The element has a cloverleaf like secondary structure and is known to be a multifunctional cis-acting replication element (CRE), required for the initiation of negative strand RNA synthesis.{{cite journal | vauthors = Barton DJ, O'Donnell BJ, Flanegan JB | title = 5′ cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesis | journal = The EMBO Journal | volume = 20 | issue = 6 | pages = 1439–1448 | date = March 2001 | pmid = 11250909 | pmc = 145522 | doi = 10.1093/emboj/20.6.1439 }}