Ephrin A3

{{Short description|Protein-coding gene in the species Homo sapiens}}

Ephrin A3 is a protein that in humans is encoded by the EFNA3 gene.{{cite journal | vauthors = Cerretti DP, Lyman SD, Kozlosky CJ, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW | title = The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3 | journal = Genomics | volume = 33 | issue = 2 | pages = 277–82 |date=Jan 1997 | pmid = 8660976 | doi = 10.1006/geno.1996.0192 | url = https://zenodo.org/record/1229677 }}{{cite web | title = Entrez Gene: EFNA3 ephrin-A3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1944}}

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin.

References

{{cite journal | vauthors=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development |journal=Annu. Rev. Neurosci. |volume=21 |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
{{cite journal | author=Zhou R |title=The Eph family receptors and ligands |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=10.1016/S0163-7258(97)00112-5 }}
{{cite journal | vauthors=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |doi=10.1242/dev.126.10.2033 |pmid= 10207129 }}
{{cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly |journal=Int. Rev. Cytol. |volume=196 |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=10.1016/S0074-7696(00)96005-4 | series=International Review of Cytology | isbn=978-0-12-364600-2 }}
{{cite journal | vauthors=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning |journal=Philos. Trans. R. Soc. Lond. B Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 | pmc=1692797 }}
{{cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=10.1038/35058515 |s2cid=205014301 }}
{{cite journal | author=Kozlosky CJ |title=Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins |journal=Oncogene |volume=10 |issue= 2 |pages= 299–306 |year= 1995 |pmid= 7838529 |name-list-style=vanc| author2=Maraskovsky E | author3=McGrew JT | display-authors=3 | last4=Vandenbos | first4=T | last5=Teepe | first5=M | last6=Lyman | first6=SD | last7=Srinivasan | first7=S | last8=Fletcher | first8=FA | last9=Gayle Rb | first9=3rd }}
{{cite journal | author=Davis S |title=Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity |journal=Science |volume=266 |issue= 5186 |pages= 816–9 |year= 1994 |pmid= 7973638 |doi=10.1126/science.7973638 |name-list-style=vanc| author2=Gale NW | author3=Aldrich TH | display-authors=3 | last4=Maisonpierre | first4=P. | last5=Lhotak | first5=V | last6=Pawson | first6=T | last7=Goldfarb | first7=M | last8=Yancopoulos | first8=G. |bibcode=1994Sci...266..816D }}
{{cite journal | author=Gale NW |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=10.1016/S0896-6273(00)80276-7 |name-list-style=vanc| author2=Holland SJ | author3=Valenzuela DM | display-authors=3 | last4=Flenniken | first4=Ann | last5=Pan | first5=Li | last6=Ryan | first6=Terrence E | last7=Henkemeyer | first7=Mark | last8=Strebhardt | first8=Klaus | last9=Hirai | first9=Hisamaru |s2cid=1075856 | doi-access=free }}
{{cite journal | author= Ephnomenclaturecommittee|title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=10.1016/S0092-8674(00)80500-0 |s2cid=26773768 |doi-access=free }}
{{cite journal | vauthors=Janis LS, Cassidy RM, Kromer LF |title=Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum |journal=J. Neurosci. |volume=19 |issue= 12 |pages= 4962–71 |year= 1999 |pmid= 10366629 |doi= 10.1523/JNEUROSCI.19-12-04962.1999|pmc=6782661 |doi-access=free }}
{{cite journal | author=Stein E |title=A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting |journal=J. Neurosci. |volume=19 |issue= 20 |pages= 8885–93 |year= 1999 |pmid= 10516308 |doi= 10.1523/JNEUROSCI.19-20-08885.1999|name-list-style=vanc| author2=Savaskan NE | author3=Ninnemann O | display-authors=3 | last4=Nitsch | first4=R | last5=Zhou | first5=R | last6=Skutella | first6=T |pmc=6782767 | doi-access=free}}
{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}

Ephrin A3

References

Further reading