Equilibrative nucleoside transporter 2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.{{cite journal | vauthors = Williams JB, Rexer B, Sirripurapu S, John S, Goldstein R, ((Phillips JA III)), Haley LL, Sait SN, Shows TB, Smith CM, Gerhard DS | title = The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome | journal = Genomics | volume = 42 | issue = 2 | pages = 325–30 |date=Sep 1997 | pmid = 9192854 | doi = 10.1006/geno.1997.4751 }}{{cite journal | vauthors = Crawford CR, Patel DH, Naeve C, Belt JA | title = Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line | journal = J Biol Chem | volume = 273 | issue = 9 | pages = 5288–93 |date=Mar 1998 | pmid = 9478986 | doi = 10.1074/jbc.273.9.5288| doi-access = free }}{{cite web | title = Entrez Gene: SLC29A2 solute carrier family 29 (nucleoside transporters), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3177}}
See also
References
{{Reflist|2}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Baldwin SA, Beal PR, Yao SY |title=The equilibrative nucleoside transporter family, SLC29. |journal=Pflügers Arch. |volume=447 |issue= 5 |pages= 735–43 |year= 2004 |pmid= 12838422 |doi= 10.1007/s00424-003-1103-2 |s2cid=8817821 |display-authors=etal}}
- {{cite journal | vauthors=Mangravite LM, Badagnani I, Giacomini KM |title=Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney |journal=Eur. J. Pharmacol. |volume=479 |issue= 1–3 |pages= 269–81 |year= 2004 |pmid= 14612157 |doi=10.1016/j.ejphar.2003.08.076 }}
- {{cite journal | vauthors=Williams JB, Lanahan AA |title=A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein. |journal=Biochem. Biophys. Res. Commun. |volume=213 |issue= 1 |pages= 325–33 |year= 1995 |pmid= 7639753 |doi= 10.1006/bbrc.1995.2133 |doi-access= free }}
- {{cite journal | vauthors=Griffiths M, Yao SY, Abidi F |title=Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. |journal=Biochem. J. |volume=328 |issue= 3|pages= 739–43 |year= 1998 |pmid= 9396714 |doi= 10.1042/bj3280739|pmc=1218980|display-authors=etal}}
- {{cite journal | vauthors=Yao SY, Ng AM, Vickers MF |title=Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24938–48 |year= 2002 |pmid= 12006583 |doi= 10.1074/jbc.M200966200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Molina-Arcas M, Bellosillo B, Casado FJ |title=Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. |journal=Blood |volume=101 |issue= 6 |pages= 2328–34 |year= 2003 |pmid= 12411296 |doi= 10.1182/blood-2002-07-2236 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Mangravite LM, Xiao G, Giacomini KM |title=Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 5 |pages= F902–10 |year= 2003 |pmid= 12527552 |doi= 10.1152/ajprenal.00215.2002 }}
- {{cite journal | vauthors=Ward JL, Leung GP, Toan SV, Tse CM |title=Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2. |journal=Arch. Biochem. Biophys. |volume=411 |issue= 1 |pages= 19–26 |year= 2003 |pmid= 12590919 |doi=10.1016/S0003-9861(02)00718-X }}
- {{cite journal | vauthors=Szkotak AJ, Ng AM, Man SF |title=Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells. |journal=J. Membr. Biol. |volume=192 |issue= 3 |pages= 169–79 |year= 2003 |pmid= 12820662 |doi=10.1007/s00232-002-1073-x |s2cid=23060872 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Farré X, Guillén-Gómez E, Sánchez L |title=Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. |journal=Int. J. Cancer |volume=112 |issue= 6 |pages= 959–66 |year= 2004 |pmid= 15386342 |doi= 10.1002/ijc.20524 |s2cid=33828164 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
- {{cite journal | vauthors=Visser F, Zhang J, Raborn RT |title=Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites. |journal=Mol. Pharmacol. |volume=67 |issue= 4 |pages= 1291–8 |year= 2005 |pmid= 15644498 |doi= 10.1124/mol.104.005884 |s2cid=22594104 |display-authors=etal}}
- {{cite journal | vauthors=Visser F, Baldwin SA, Isaac RE |title=Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters. |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 11025–34 |year= 2005 |pmid= 15649894 |doi= 10.1074/jbc.M410348200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Owen RP, Lagpacan LL, Taylor TR |title=Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. |journal=Drug Metab. Dispos. |volume=34 |issue= 1 |pages= 12–5 |year= 2006 |pmid= 16214850 |doi= 10.1124/dmd.105.006270 |s2cid=6396393 |display-authors=etal}}
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{{NLM content}}
{{Purinergics}}
{{Membrane transport proteins}}
Category:Solute carrier family
Category:Neurotransmitter transporters
{{membrane-protein-stub}}