Estradiol/medroxyprogesterone acetate

{{Short description|Pharmaceutical drug combination}}

{{Drugbox

| image = Estradiol.svg

| width = 225px

| caption =

| image2 = Medroxyprogesterone acetate.svg

| width2 = 250px

| caption2 = Estradiol (top) and medroxy-
progesterone acetate (bottom)

| type = combo

| drug_name = Estradiol /
medroxyprogesterone acetate

| component1 = Estradiol

| class1 = Estrogen

| component2 = Medroxyprogesterone acetate

| class2 = Progestogen

| tradename = Indivina, Tridestra

| Drugs.com =

| MedlinePlus =

| pregnancy_AU =

| pregnancy_US =

| pregnancy_category =

| legal_AU =

| legal_CA =

| legal_UK =

| legal_US = Rx-only

| routes_of_administration = By mouth

| class = Estrogen; Progestogen

| CAS_number = 215930-42-0

| ATC_prefix =

| ATC_suffix =

| PubChem = 66978539

| DrugBank =

| synonyms = E2/MPA

}}

Estradiol/medroxyprogesterone acetate (E2/MPA), sold under the brand names Indivina and Tridestra among others, is a combination product of estradiol, an estrogen, and medroxyprogesterone acetate, a progestogen, which is used in menopausal hormone therapy for the treatment of menopausal symptoms.{{cite book| vauthors = Clunie G, Keen RW |title=Osteoporosis|url=https://books.google.com/books?id=SIgdBAAAQBAJ&pg=PT74|year=2014|publisher=Oxford University Press|isbn=978-0-19-871334-0|pages=74–}} It is taken by mouth.

{{Health risks in the conjugated estrogens and medroxyprogesterone acetate substudy of the Women's Health Initiative}}