Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate

{{Short description|Combination drug}}

{{Drugbox

| type = combo

| drug_name = Estradiol benzoate /
estradiol valerate /
hydroxyprogesterone caproate

| component1 = Estradiol benzoate

| class1 = Estrogen

| component2 = Estradiol valerate

| class2 = Estrogen

| component3 = Hydroxyprogesterone caproate

| class3 = Progestogen

| tradename = Sin-Ol

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| routes_of_administration = Intramuscular injection

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| synonyms = EB/EV/OHPC

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Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate (EB/EV/OHPC), sold under the brand name Sin-Ol, is a combination medication of estradiol benzoate (EB), an estrogen, estradiol valerate (EV), an estrogen, and hydroxyprogesterone caproate (OHPC), a progestin, which was reportedly used as a combined injectable contraceptive in women in the early 1970s.{{cite book | vauthors = Rudel HW, Kinel FA | chapter = Oral Contraceptives. Human Fertility Studies and Side Effects | pages = 385–469 | veditors = Tausk M | title = Pharmacology of the Endocrine System and Related Drugs: Progesterone, Progestational Drugs and Antifertility Agents | volume = II | url = https://books.google.com/books?id=Nv5sAAAAMAAJ | date = September 1972 | publisher = Pergamon Press | isbn = 978-0080168128 | oclc = 278011135}} It contained 1 mg EB, 10 mg EV, and 250 mg OHPC in oil solution, was provided in the form of 3 mL ampoules, and was administered by intramuscular injection at regular intervals. The medication was manufactured by the pharmaceutical company Reuffer in Mexico.