Estradiol benzoate/progesterone/testosterone propionate

{{Short description|Combination drug}}

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| type = combo

| drug_name = EB/P4/TP

| component1 = Estradiol benzoate

| class1 = Estrogen

| component2 = Progesterone

| class2 = Progestogen

| component3 = Testosterone propionate

| class3 = Androgen; Anabolic steroid

| tradename = Lukestra, Steratrin, Trihormonal, Trinestryl

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| routes_of_administration = Intramuscular injection

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| synonyms = EB/P4/TP

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Estradiol benzoate/progesterone/testosterone propionate (EB/P4/TP), sold under the brand names Lukestra, Steratrin, Trihormonal, and Trinestryl, is an injectable combination medication of estradiol benzoate (EB), an estrogen, progesterone (P4), a progestogen, and testosterone propionate (TP), an androgen/anabolic steroid.{{cite book | vauthors = Silló G | chapter = Komplexhormon bei Menopause und Hypertonie | trans-chapter = Complex hormone for menopause and hypertension | veditors = Nowakowski H |title=Hormone und Psyche die Endokrinologie des Alternden Menschen: Fünftes Symposion der Deutschen Gesellschaft für Endokrinologie Freiburg (Breisgau), den 7. bis 9. März 1957 | trans-title = Hormones and Psyche the Endocrinology of Aging People: Fifth Symposium of the German Society for Endocrinology Freiburg (Breisgau), March 7th to 9th, 1957 | chapter-url = https://books.google.com/books?id=4NKEBwAAQBAJ&pg=PA55|date=9 March 2013|publisher=Springer-Verlag|isbn=978-3-642-87014-9|pages=55–}}{{cite book| vauthors = Hager HH, Kern W, List PH, Roth HJ | chapter = Hormone |title=Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Ärzte und Medizinalbeamte: Wirkstoffgruppen II Chemikalien und Drogen (A-AL)| chapter-url = https://books.google.com/books?id=a2a0BgAAQBAJ&pg=PA187|date=29 July 2013|publisher=Springer-Verlag|isbn=978-3-662-25655-8|pages=187–}}{{cite book| vauthors = Walther K, Auterhoff H, Neuwald F, Schmid W | chapter = Hormone |title=Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Drogisten, Ärzte und Medizinalbeamte| chapter-url=https://books.google.com/books?id=C_SgBgAAQBAJ&pg=PA1163|date=9 March 2013|publisher=Springer-Verlag|isbn=978-3-642-49759-9|pages=1163–}}{{cite book| vauthors = Ufer J |title=Hormontherapie in der Frauenheilkunde: Grundlagen und Praxis|url=https://books.google.com/books?id=wcRsAAAAMAAJ|year=1960|publisher=de Gruyter|page=155| isbn = 9783111138770 }}{{cite book | vauthors = Bishop PM |title=Chemistry of the Sex Hormones|url=https://books.google.com/books?id=Lb3wAAAAMAAJ|year=1962|publisher=Thomas|page=85|quote=Lukestra Injection Steroid Triad (oestradiol benz., test. prop. and progesterone) Merck, Sharp & Dohme}} It contained 1 to 3 mg EB, 20 to 25 mg P4, and 25 mg TP, was provided in the form of ampoules, and was administered by intramuscular injection.{{cite journal | vauthors = Greenblatt RB, Barfield WE | title = Hormonal control of functional uterine bleeding | journal = American Journal of Obstetrics and Gynecology | volume = 63 | issue = 1 | pages = 153–157 | date = January 1952 | pmid = 14894511 | doi = 10.1016/s0002-9378(16)38992-x | quote = The estrogen-progesterone-testosterone combinations used in our studies were supplied by the following pharmaceutical companies: Wyeth, Inc.: Tristerone (6 mg. estrone, 50 mg. progesterone, 25 mg. testosterone). Schering Corporation: Steratrin (1 mg. estradiol benzoate, 25 mg. progesterone, 25 mg. testoterone propionate).Sharp and Dohme, Inc.: Lukestra (1.66 mg. estradiol benzoate, 25 mg. progesterone, 25 mg. testosterone propionate). | s2cid = 6863371 }} The medication was introduced by 1949 and was marketed in the United States, the United Kingdom, and Germany among other places.{{cite book|author=United States. Patent Office|title=Official Gazette of the United States Patent Office|url=https://books.google.com/books?id=kXAbAQAAMAAJ&pg=PA31|year=1950|publisher=U.S. Patent Office.|pages=31–}}{{cite book|title=Unlisted Drugs|url=https://books.google.com/books?id=BgVtAAAAMAAJ|year=1952|publisher=Unlisted Drugs Committee of the Pharmaceutical Section, Science-Technology Group, Special Libraries Association|quote=Lukestra C. each cc, contains: estradiol benzoate, 1.67 mg.; progesterone, 25 mg.; and testosterone propionate, 25 mg.}} It is no longer available.{{cite web | title = ? | url = https://www.micromedexsolutions.com/ | work = IBM Watson Health }}{{cite web | title = Estradiol | url = https://www.drugs.com/international/estradiol.html | work = Drugs.com }}