Estradiol cypionate/hydroxyprogesterone caproate

{{Short description|Combination drug}}

{{Drugbox

| image = Estradiol 17 beta-cypionate.svg

| width = 250px

| caption =

| image2 = Hydroxyprogesterone caproate.svg

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| caption2 = Estradiol cypionate (top) and
hydroxyprogesterone caproate (bottom)

| type = combo

| drug_name = Estradiol cypionate /
hydroxyprogesterone caproate

| component1 = Estradiol cypionate

| class1 = Estrogen

| component2 = Hydroxyprogesterone caproate

| class2 = Progestogen

| tradename = Sinbios

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| routes_of_administration = Intramuscular injection

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| synonyms = EC/OHPC

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Estradiol cypionate/hydroxyprogesterone caproate (EC/OHPC), sold under the brand name Sinbios, is a combination medication of estradiol cypionate (EC), an estrogen, and hydroxyprogesterone caproate (OHPC), a progestin, which was reportedly used as a combined injectable contraceptive in women in the early 1970s.{{cite book | vauthors = Rudel HW, Kinel FA | chapter = Oral Contraceptives. Human Fertility Studies and Side Effects | pages = 385–469 | veditors = Tausk M | title = Pharmacology of the Endocrine System and Related Drugs: Progesterone, Progestational Drugs and Antifertility Agents | volume = II | url = https://books.google.com/books?id=Nv5sAAAAMAAJ | date = September 1972 | publisher = Pergamon Press | isbn = 978-0080168128 | oclc = 278011135}} It contained 5 mg EC and 250 mg OHPC in oil solution, was provided in the form of 1 mL ampoules, and was administered by intramuscular injection at regular intervals. The medication was manufactured by the pharmaceutical company Mavi in Mexico.