Ethinylestradiol/megestrol acetate

{{Short description|Combination drug}}

{{Drugbox

| image = Ethinylestradiol.svg

| width = 235px

| caption = Ethinylestradiol

| image2 = Megestrol acetate.svg

| width2 = 235px

| caption2 = Megestrol acetate

| type = combo

| drug_name = Ethinylestradiol/megestrol acetate

| component1 = Ethinylestradiol

| class1 = Estrogen

| component2 = Megestrol acetate

| class2 = Progestogen; Progestin

| tradename = Nuvacon, Volidan

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| pregnancy_AU =

| pregnancy_US =

| pregnancy_category =

| legal_AU =

| legal_CA =

| legal_UK =

| legal_US = Rx-only

| routes_of_administration = By mouth

| class = Estrogen; Progestin; Progestogen

| CAS_number = 8064-66-2

| ATC_prefix =

| ATC_suffix =

| PubChem = 66446

| DrugBank =

| synonyms = EE/MGA

}}

Ethinylestradiol/megestrol acetate (EE/MGA), sold under the brand name Volidan among others, was a combination of ethinylestradiol (EE), an estrogen, and megestrol acetate (MGA), a progestin, which was used as a birth control pill to prevent pregnancy in women.{{cite book|author=Lara Marks|title=Sexual Chemistry: A History of the Contraceptive Pill|url=https://books.google.com/books?id=GgvLA3bqwnoC&pg=PA77|year=2001|publisher=Yale University Press|isbn=978-0-300-08943-1|pages=77–78}}{{cite journal | vauthors = Mears E | title = A new type of oral contraceptive | journal = Br Med J | volume = 1 | issue = 5341 | pages = 1318–20 | year = 1963 | pmid = 13934321 | pmc = 2123904 | doi = 10.1136/bmj.1.5341.1318}} It was taken by mouth and contained 50 to 100 μg EE and 1 to 5 mg MGA per tablet. MGA-containing birth control pills were withdrawn after reports in the early 1970s of a high incidence of venous thromboembolism in association with the preparations.{{cite journal | vauthors = El Makhzangy MN, Wynn V, Lawrence DM | title = Sex hormone binding globulin capacity as an index of oestrogenicity or androgenicity in women on oral contraceptive steroids | journal = Clinical Endocrinology | volume = 10 | issue = 1 | pages = 39–45 | date = January 1979 | pmid = 571314 | doi = 10.1111/j.1365-2265.1979.tb03031.x | s2cid = 7262495 }}