Eva Gottwein
{{short description|American virologist}}
{{Infobox scientist
| name = Eva H. Gottwein
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| fields = Virology, Microbiology, Immunology
| workplaces = Northwestern University Feinberg School of Medicine
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| education = Postdoctoral: Duke University 2010
PhD, Biology: Heidelberg University 2005
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Eva Henriette Gottwein is a virologist and Associate Professor of Microbiology-Immunology at Northwestern University Feinberg School of Medicine in Chicago, Illinois. The main focus of her research is the role of viral miRNAs involved in herpesviral oncogenesis.{{cite web|title=Faculty Profiles|url=http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=20051|website=Northwestern University Feinberg School of Medicine|publisher=Northwestern University}} Gottwein is member of Robert H. Lurie Comprehensive Cancer Center of Northwestern University. Her contributions as a member include the focus on how encoded miRNAs target and function in the human oncogenic herpesvirus Kaposi's sarcoma-associated herpesvirus known as KSHV.{{cite web|title=Research and Education|url=http://cancer.northwestern.edu/research/members_directory/members_bio.cfm?id=528|website=Robert H. Lurie Comprehensive Cancer Center of Northwestern University}}
Education and career
Gottwein received her PhD in biology from Heidelberg University in 2005.
During her postdoctoral work, Eva Gottwein studied herpesviral miRNA in Bryan Cullen's laboratory at Duke University.{{cite web|title=Faculty Profile: Eva Gottwein, PhD, Assistant Professor of Microbiology-Immunology|url=http://www.feinberg.northwestern.edu/research/news/faculty/E-Gottwein.html|website=Northwestern Medicine|access-date=2015-05-11|archive-url=https://web.archive.org/web/20150518090409/http://www.feinberg.northwestern.edu/research/news/faculty/E-Gottwein.html|archive-date=2015-05-18|url-status=dead}} Eva Gottwein currently is an associate professor of microbiology-immunology at Northwestern University Feinberg School of Medicine.
Research contributions
The focus of her work involves identifying the function of microRNAs that are encoded in the human herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV). KSHV causes tumors by infecting endothelial cells. Since the AIDS epidemic in Africa, KSHV is also known to attack and infect B lymphocytes, which results in a person having B cell lymphomas and effusion lymphoma.{{cite web|title=Gottwein Lab Northwestern University Department of Microbiology-Immunology|url=http://bugs.mimnet.northwestern.edu/labs/gottweinlab/index.html|website=Gottwein Lab|access-date=2015-05-10|archive-url=https://web.archive.org/web/20150201223648/http://bugs.mimnet.northwestern.edu/labs/gottweinlab/index.html|archive-date=2015-02-01|url-status=dead}} Prior to her laboratory experience at Duke University, the target for KSHV microRNAs were unknown. Gottwein recently studied the expression of KSHV mRNAs. Through her research she found that Kaposi's sarcoma-associated herpesvirus (KSHV) has nearly 20 viral mRNAs. During her research she discovered that miR-K10 by itself has the ability to transform cells.{{cite journal|last1=Forte|first1=E|last2=Raja|first2=A|last3=Shamulaitlatpam|first3=P|last4=Manzano|first4=M|last5=Schipma|first5=MJ|last6=Casey|first6=JL|last7=Gottwein|first7=E|title=MicroRNA- mediated transformation by the Kaposi's sacromaassociated herpesvirus Kaposin locus|journal= Journal of Virology|date= 2015|volume=89|issue=4|pages=2333–2341|doi=10.1128/JVI.03317-14|pmid=25505059|pmc=4338870}} In another experiment, Gottwein research found that the function of miRNA KSHV proteins that were used to target certain cellular RNAs. Through her experiment she discovered abnormal ligand reactions that occurred during the absence of exogenous ligase and a unique miRNA binding site.{{cite journal|last1=Grosswendt|first1=S|last2=Filipchyk|first2=A|last3=Manzano|first3=M|last4=Kilronomos|first4=F|last5=Schilling|first5=M|last6=Herzog|first6=M|last7=Gottwein|first7=E|last8=Rajewsky|first8=N|title=Unambiguous Identification of miRNA: Target site interactions by different types of ligation reactions|journal=Molecular Cell|date= 2015|volume=54|issue=6|pages=1042–1054|doi=10.1016/j.molcel.2014.03.049|pmid=24857550|pmc=4181535}} Her goal for the next few years is to learn more about the targetome of the KSHV microRNAs and identification of the virus' functions in oncogenesis.
File:Kaposis Sarcoma Lesions.jpg
Image:Kaposi sarcoma high mag.jpg of Kaposi sarcoma. H&E stain.]]
Notable publications
- {{cite journal | last1 = Forte | first1 = Eleonora | last2 = Raja | first2 = Archana N. | last3 = Shamulailatpam | first3 = Priscilla | last4 = Manzano | first4 = Mark | last5 = Schipma | first5 = Matthew J. | last6 = Casey | first6 = John L. | last7 = Gottwein | first7 = Eva | title = MicroRNA-mediated transformation by the Kaposi's sacromaassociated herpesvirus Kaposin locus | journal = Journal of Virology | volume = 89 | issue = 4| pages = 2333–2341 | doi=10.1128/jvi.03317-14 | pmid=25505059 | pmc=4338870| date = 2015-02-15 }}
- {{cite journal | last1 = Khare | first1 = Sonal | last2 = Ratsimandresy | first2 = Rojo A. | last3 = De Almeida | first3 = Lucia | last4 = Cuda | first4 = Carla M. | last5 = Rellick | first5 = Stephanie L. | last6 = Misharin | first6 = Alexander V. | last7 = Wallin | first7 = Melissa C. | last8 = Gangopadhyay | first8 = Anu | last9 = Forte | first9 = Eleonora | last10 = Gottwein | first10 = Eva | title = The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses | journal = Nature Immunology | volume = 15 | issue = 4| pages = 343–353 | doi=10.1038/ni.2829| pmid = 24531343 | pmc = 4123781 | date = April 2014 }}
- {{cite journal | last1 = Gottwein | first1 = Eva | year = 2012| title = Kaposi's sarcoma-associated herpesvirus microRNAs | journal = Frontiers in Microbiology | volume = 3 | pages = 165 | pmc=3342587 | pmid=22563327 | doi=10.3389/fmicb.2012.00165| doi-access = free }}
- {{cite journal | last1 = Gottwein | first1 = Eva | last2 = Corcoran | first2 = David L. | last3 = Mukherjee | first3 = Neelanjan | last4 = Skalsky | first4 = Rebecca L. | last5 = Hafner | first5 = Markus | last6 = Nusbam | first6 = Jeffrey D. | last7 = Shamulailatpam | first7 = Priscilla | last8 = Love | first8 = Cassandra L. | last9 = Dave | first9 = Sandeep S. | last10 = Tuschl | first10 = Thomas | title = viral microrna targetome of kshv-infected primary effusion lymphoma cell lines | journal = Cell Host and Microbe | volume = 10 | issue = 5| pages = 515–526 | doi=10.1016/j.chom.2011.09.012 | pmid=22100165 | pmc=3222872| date = 2011-11-17 }}
- {{cite journal | last1 = Gottwein | first1 = Eva | last2 = Cullen | first2 = Bryan R. | title = A human herpesvirus MicroRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest | journal = Journal of Virology | volume = 84 | issue = 10| pages = 5229–5237 | doi=10.1128/jvi.00202-10| pmid = 20219912 | pmc = 2863803 | date = 2010-05-15 }}
- {{cite journal | last1 = Gottwein | first1 = Eva | last2 = Cullen | first2 = Bryan R. | title = Viral and Cellular MicroRNAs as Determinants of Viral Pathogenesis and Immunity | journal = Cell Host and Microbe | volume = 3 | issue = 6| pages = 375–387 | doi=10.1016/j.chom.2008.05.002| pmid = 18541214 | pmc = 3079432 | date = 2008-06-12 }}
- {{cite journal | last1 = Gottwein | first1 = Eva | last2 = Mukherjee | first2 = Neelanjan | last3 = Sachse | first3 = Christoph | last4 = Frenzel | first4 = Corina | last5 = Majoros | first5 = William H. | last6 = Jen- | last7 = Chi | first7 = Tsan A. | last8 = Braich | first8 = Ravi | last9 = Manoharan | first9 = Muthiah | last10 = Soutschek | first10 = Jurgen | last11 = Ohler | first11 = Uwe | title = A viral microRNA functions as an orthologue of cellular miR-155 | journal = Nature | volume = 450 | issue = 7172| pages = 1096–1099 | doi=10.1038/nature05992 | pmid=18075594 | pmc=2614920| date = December 2007 | bibcode = 2007Natur.450.1096G }}
- {{cite journal | last1 = Gottwein | first1 = Eva | last2 = Cai | first2 = Xuezhong | last3 = Cullen | first3 = Bryan R. | title = A novel assay for viral microRNA function identifies a single nucleotide polymorphism that affects Drosha processing | journal = Journal of Virology | volume = 80 | issue = 11| pages = 5321–5326 | doi=10.1128/jvi.02734-05| pmid = 16699012 | pmc = 1472151 | date = June 2006 }}
- {{cite journal | last1 = Gottwein | first1 = Eva | last2 = Jager | first2 = Stefanie | last3 = Habermann | first3 = Anja | last4 = Krausslich | first4 = Hans-Georg | title = Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 Gag cause a late budding defect | journal = Journal of Virology | volume = 80 | issue = 13| pages = 6267–6275 | doi=10.1128/jvi.02177-05| pmid = 16775314 | pmc = 1488962 | date = July 2006 }}
- {{cite journal | last1 = Gottwein | first1 = Eva | last2 = Krausslich | first2 = Hans-Georg | title = Analysis of human immunodeficiency virus type 1 Gag ubiquitination | journal = Journal of Virology | volume = 79 | issue = 14| pages = 9134–9144 | doi=10.1128/jvi.79.14.9134-9144.2005 | pmid=15994808 | pmc=1168789| date = July 2005 }}
- {{cite journal | last1 = Gottwein | first1 = Eva | last2 = Bodem | first2 = Jochen | last3 = Muller | first3 = Barbara | last4 = Schmechel | first4 = Ariane | last5 = Zentgraf | first5 = Hanswalter | last6 = Krausslich | first6 = Hans-Georg | title = The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release | journal = Journal of Virology | volume = 77 | issue = 17| pages = 9474–9485 | doi=10.1128/jvi.77.17.9474-9485.2003| pmid = 12915562 | pmc = 187385 | date = September 2003 }}
References
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Category:Year of birth missing (living people)