Examples of in vivo transdifferentiation by lineage-instructive approach
{{Short description|List of examples of in vivo transdifferentiation through transfection}}
A list of examples of in vivo transdifferentiation through transfection:{{Cite journal
| last1 = Pournasr | first1 = B.
| last2 = Khaloughi | first2 = K.
| last3 = Salekdeh | first3 = G. H.
| last4 = Totonchi | first4 = M.
| last5 = Shahbazi | first5 = E.
| last6 = Baharvand | first6 = H.
| doi = 10.1002/stem.760
| title = Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells
| journal = Stem Cells
| volume = 29
| issue = 12
| pages = 1933–1941
| year = 2011
| pmid = 21997905
| pmc =
| doi-access = free
}}
- mouse hepatocytes → B cells (Pdx1){{Cite journal
| last1 = Ferber | first1 = S.
| last2 = Halkin | first2 = A.
| last3 = Cohen | first3 = H.
| last4 = Ber | first4 = I.
| last5 = Einav | first5 = Y.
| last6 = Goldberg | first6 = I.
| last7 = Barshack | first7 = I.
| last8 = Seijffers | first8 = R.
| last9 = Kopolovic | first9 = J.
| last10 = Kaiser | first10 = N.
| last11 = Karasik | first11 = A.
| title = Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
| journal = Nature Medicine
| volume = 6
| issue = 5
| pages = 568–572
| doi = 10.1038/75050
| year = 2000
| pmid = 10802714
| pmc =
| s2cid = 19015530
}}
- exocrine cells → B cells (Pdx1, Ngn3, and v-maf musculoaponeurotic fibrosarcoma oncogene family protein A){{Cite journal
| last1 = Zhou | first1 = Q.
| last2 = Brown | first2 = J.
| last3 = Kanarek | first3 = A.
| last4 = Rajagopal | first4 = J.
| last5 = Melton | first5 = D. A.
| title = In vivo reprogramming of adult pancreatic exocrine cells to β-cells
| doi = 10.1038/nature07314
| journal = Nature
| volume = 455
| issue = 7213
| pages = 627–632
| year = 2008
| pmid = 18754011
| pmc =9011918
| bibcode = 2008Natur.455..627Z
| s2cid = 205214877
}}
- nonsensory cells → inner hair cells (Atoh1 and MathI){{Cite journal
| last1 = Izumikawa | first1 = M.
| last2 = Minoda | first2 = R.
| last3 = Kawamoto | first3 = K.
| last4 = Abrashkin | first4 = K. A.
| last5 = Swiderski | first5 = D. L.
| last6 = Dolan | first6 = D. F.
| last7 = Brough | first7 = D. E.
| last8 = Raphael | first8 = Y.
| doi = 10.1038/nm1193
| title = Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals
| journal = Nature Medicine
| volume = 11
| issue = 3
| pages = 271–276
| year = 2005
| pmid = 15711559
| pmc =
| s2cid = 18319476
}}
- non cardiogenic mesoderm → cardiomyocytes (Gata4, Tbx5 and Smarcd3 or Baf60c){{Cite journal
| last1 = Takeuchi | first1 = J. K.
| last2 = Bruneau | first2 = B. G.
| doi = 10.1038/nature08039
| title = Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors
| journal = Nature
| volume = 459
| issue = 7247
| pages = 708–711
| year = 2009
| pmid = 19396158
| pmc =2728356
| bibcode = 2009Natur.459..708T
}}
Through excision:
- B-cell precursors → hematopoietic progenitors(-Pax5){{Cite journal
| last1 = Cobaleda | first1 = C. S.
| last2 = Jochum | first2 = W.
| last3 = Busslinger | first3 = M.
| doi = 10.1038/nature06159
| title = Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
| journal = Nature
| volume = 449
| issue = 7161
| pages = 473–477
| year = 2007
| pmid = 17851532
| pmc =
| bibcode = 2007Natur.449..473C
| s2cid = 4414856
}}
- In adult ovarian follicles, granulosa and thecal cells → functional Sertoli-like and Leydig-like cells (-Foxl1){{Cite journal
| last1 = Uhlenhaut | first1 = N. H.
| last2 = Jakob | first2 = S.
| last3 = Anlag | first3 = K.
| last4 = Eisenberger | first4 = T.
| last5 = Sekido | first5 = R.
| last6 = Kress | first6 = J.
| last7 = Treier | first7 = A. C.
| last8 = Klugmann | first8 = C.
| last9 = Klasen | first9 = C.
| doi = 10.1016/j.cell.2009.11.021
| last10 = Holter | first10 = N. I.
| last11 = Riethmacher | first11 = D.
| last12 = Schütz | first12 = G. N.
| last13 = Cooney | first13 = A. J.
| last14 = Lovell-Badge | first14 = R.
| last15 = Treier | first15 = M.
| title = Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation
| journal = Cell
| volume = 139
| issue = 6
| pages = 1130–1142
| year = 2009
| pmid = 20005806
| pmc =
| doi-access = free
}}