Exosite

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An exosite is a secondary binding site, remote from the active site, on an enzyme or other protein.{{cite journal |last1=Yegneswaran |first1=S. |last2=Tiefenbrunn |first2=T. K. |last3=Fernández |first3=J. A. |last4=Dawson |first4=P. E. |title=Manipulation of thrombin exosite I, by ligand-directed covalent modification |journal=Journal of Thrombosis and Haemostasis |date=October 2007 |volume=5 |issue=10 |pages=2062–2069 |doi=10.1111/j.1538-7836.2007.02712.x |pmid=17883702 |s2cid=38198958 |doi-access=free }}

This is similar to allosteric sites, but differs in the fact that, in order for an enzyme to be active, its exosite typically must be occupied.{{cite journal |last1=Lockett |first1=J. M. |last2=Sheehan |first2=J. P. |last3=Mast |first3=A. E. |title=Binding at two distinct exosites is required for activation of prothrombin by prothrombinase |journal=Journal of Thrombosis and Haemostasis |volume=1 |issue=Supplement 1 |date=July 2003 |url=http://www.blackwellpublishing.com/isth2003/abstract.asp?id=9231 |archive-url=https://web.archive.org/web/20041126131935/http://www.blackwellpublishing.com/isth2003/abstract.asp?id=9231 |archive-date=2004-11-26 }} Exosites have recently become a topic of increased interest in biomedical research as potential drug targets.{{cite journal |last1=Müller |first1=Jens |last2=Isermann |first2=Berend |last3=Dücker |first3=Christina |last4=Salehi |first4=Mohammad |last5=Meyer |first5=Moritz |last6=Friedrich |first6=Max |last7=Madhusudhan |first7=Thati |last8=Oldenburg |first8=Johannes |last9=Mayer |first9=Günter |last10=Pötzsch |first10=Bernd |title=An Exosite-Specific ssDNA Aptamer Inhibits the Anticoagulant Functions of Activated Protein C and Enhances Inhibition by Protein C Inhibitor |journal=Chemistry & Biology |date=April 2009 |volume=16 |issue=4 |pages=442–451 |doi=10.1016/j.chembiol.2009.03.007 |pmid=19389630 |doi-access= }}{{cite book |title=Serine Endopeptidases: Advances in Research and Application: 2011 Edition |date=2012 |publisher=ScholarlyEditions |isbn=978-1-4649-2658-7 }}{{pn|date=January 2022}}