F2RL3

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{{Short description|Protein-coding gene in the species Homo sapiens}}

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Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.{{cite web | title = Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9002}}

Function

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.

See also

References

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Further reading

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  • {{cite journal |vauthors=Leger AJ, Covic L, Kuliopulos A |title=Protease-activated receptors in cardiovascular diseases. |journal=Circulation |volume=114 |issue= 10 |pages= 1070–7 |year= 2006 |pmid= 16952995 |doi= 10.1161/CIRCULATIONAHA.105.574830 |s2cid=312800 |doi-access=free }}
  • {{cite journal |vauthors=Xu WF, Andersen H, Whitmore TE |title=Cloning and characterization of human protease-activated receptor 4. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6642–6 |year= 1998 |pmid= 9618465 |doi=10.1073/pnas.95.12.6642 | pmc=22580 |bibcode=1998PNAS...95.6642X |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Kahn ML, Zheng YW, Huang W |title=A dual thrombin receptor system for platelet activation. |journal=Nature |volume=394 |issue= 6694 |pages= 690–4 |year= 1998 |pmid= 9716134 |doi= 10.1038/29325 |bibcode=1998Natur.394..690K |s2cid=4408582 |display-authors=etal}}
  • {{cite journal |vauthors=Kahn ML, Hammes SR, Botka C, Coughlin SR |title=Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23290–6 |year= 1998 |pmid= 9722561 |doi=10.1074/jbc.273.36.23290 |s2cid=32777201 |doi-access=free }}
  • {{cite journal |vauthors=Kahn ML, Nakanishi-Matsui M, Shapiro MJ |title=Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. |journal=J. Clin. Invest. |volume=103 |issue= 6 |pages= 879–87 |year= 1999 |pmid= 10079109 |doi=10.1172/JCI6042 | pmc=408153 |display-authors=etal}}
  • {{cite journal |vauthors=Andersen H, Greenberg DL, Fujikawa K |title=Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11189–93 |year= 1999 |pmid= 10500152 |doi=10.1073/pnas.96.20.11189 | pmc=18009 |bibcode=1999PNAS...9611189A |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Sambrano GR, Huang W, Faruqi T |title=Cathepsin G activates protease-activated receptor-4 in human platelets. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 6819–23 |year= 2000 |pmid= 10702240 |doi=10.1074/jbc.275.10.6819 |s2cid=33219053 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Nakanishi-Matsui M, Zheng YW, Sulciner DJ |title=PAR3 is a cofactor for PAR4 activation by thrombin. |journal=Nature |volume=404 |issue= 6778 |pages= 609–13 |year= 2000 |pmid= 10766244 |doi= 10.1038/35007085 |bibcode=2000Natur.404..609N |s2cid=4410800 |display-authors=etal}}
  • {{cite journal |vauthors=Miike S, McWilliam AS, Kita H |title=Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6615–22 |year= 2002 |pmid= 11714832 |doi= 10.4049/jimmunol.167.11.6615|s2cid=9302877 |doi-access=free }}
  • {{cite journal |vauthors=Asokananthan N, Graham PT, Fink J |title=Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3577–85 |year= 2002 |pmid= 11907122 |doi= 10.4049/jimmunol.168.7.3577|s2cid=45171728 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Henriksen RA, Hanks VK |title=PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=22 |issue= 5 |pages= 861–6 |year= 2002 |pmid= 12006403 |doi=10.1161/01.ATV.0000014742.56572.25 |s2cid=24246544 |doi-access=free }}
  • {{cite journal |vauthors=Covic L, Singh C, Smith H, Kuliopulos A |title=Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome. |journal=Thromb. Haemost. |volume=87 |issue= 4 |pages= 722–7 |year= 2003 |pmid= 12008957 |doi= 10.1055/s-0037-1613071|s2cid=32831294 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | author=Owen WG |title=PAR-3 is a low-affinity substrate, high affinity effector of thrombin. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 1 |pages= 166–8 |year= 2003 |pmid= 12732212 |doi=10.1016/S0006-291X(03)00732-0 }}
  • {{cite journal |vauthors=Adam F, Verbeuren TJ, Fauchère JL |title=Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP. |journal=J. Thromb. Haemost. |volume=1 |issue= 4 |pages= 798–804 |year= 2003 |pmid= 12871418 |doi=10.1046/j.1538-7836.2003.00138.x |s2cid=12762388 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Wu CC, Hwang TL, Liao CH |title=The role of PAR4 in thrombin-induced thromboxane production in human platelets. |journal=Thromb. Haemost. |volume=90 |issue= 2 |pages= 299–308 |year= 2004 |pmid= 12888878 |doi= 10.1160/TH03-02-0103 |s2cid=4983617 |display-authors=etal}}
  • {{cite journal |vauthors=Kawai T, Akira S, Reed JC |title=ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. |journal=Mol. Cell. Biol. |volume=23 |issue= 17 |pages= 6174–86 |year= 2003 |pmid= 12917339 |doi=10.1128/MCB.23.17.6174-6186.2003 | pmc=180930 }}
  • {{cite journal |vauthors=Jacques SL, Kuliopulos A |title=Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage. |journal=Biochem. J. |volume=376 |issue= Pt 3 |pages= 733–40 |year= 2004 |pmid= 13678420 |doi= 10.1042/BJ20030954 | pmc=1223816 }}
  • {{cite journal |vauthors=Han Y, Nurden A, Combrié R, Pasquet JM |title=Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium. |journal=J. Thromb. Haemost. |volume=1 |issue= 10 |pages= 2206–15 |year= 2004 |pmid= 14521606 |doi=10.1046/j.1538-7836.2003.00436.x |s2cid=24420859 |doi-access=free }}

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{{G protein-coupled receptors}}

Category:Receptors

Category:G protein-coupled receptors

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