FANCD2OS

{{Short description|Protein-coding gene in the species Homo sapiens}}

Fanconi Anemia Opposite Strand Transcript protein is a predicted protein that in humans is encoded by the FANCD2OS gene. The name is derived from mRNA transcribed from the strand complementary to the FANCD2 gene.

Gene

The gene is encoded on Chromosome 3 (human) at p25.3 on the minus strand from 10081320-10108339nt. The primary transcript is 1105nt which codes for a protein of 177 amino acid in length. The gene on the strand complementary to FANCD2 located 5' from CYCSP11 and 3’ from BRK1 and VHL genes.

= mRNA =

There are six alternatively spliced transcripts with differences in the 5' and 3' ends as well changes in exon usage. The most common isoform is 1105 bp.{{cite web|title=Homo sapiens FANCD2 opposite strand (FANCD2OS), transcript variant 1, mRNA|url=https://www.ncbi.nlm.nih.gov/nuccore/NM_173472.1|website=NCBI Nucleotide|publisher=NCBI|accessdate=19 April 2016}}

= Promoter Region =

The promoter region predicted by the Genomatix El Dorado algorithm spans from 10108742-10108009 bp. Promoters are associated with a wide variety of tissues including B-lymphocytes, germ cells, muscle, neurons & prostate.

= Regulatory =

Secondary structure of the 5’ UTR sequence conserved between humans and gibbon contain sequence recognized by to RBMX, Ras & Rab proteins. The sequence for the secondary structure of the 3’ UTR are recognized by EIF4B and RBMX.

Expression

FANCD2OS is moderately expressed in the human brain, placenta and testes.

Evolutionary History

=Protein sequence=

The protein from the longest transcript is 177AA in length with a mass of 20188.59kD. The protein consists of a domain of unknown function from the DUF4563 superfamily.

=Orthologs=

Orthologs of FANCD2OS exist throughout mammals, reptiles, birds and in the cartilaginous fish Australian ghostshark. The protein sequence undergoes mutation at a rate similar to the blood protein fibrinogen.

Species	Common name	NCBI accession	Identity	similarity	E-value
class="wikitable"
Pongo abelii	Sumatran orangutan	[https://www.ncbi.nlm.nih.gov/protein/XP_003776240.1 XP_003776240.1]	98.9	99.4	1.21E-133
Cricetulus griseus	Chinese hamster	[https://www.ncbi.nlm.nih.gov/protein/XP_003511850.1 XP_003511850.1]	73.6	80.9	1.56E-95
Ovis aries	Sheep	[https://www.ncbi.nlm.nih.gov/protein/XP_004018322.1 XP_004018322.1]	97.2	98.3	6.79E-131
Leptonychotes weddellii	Weddell seal	[https://www.ncbi.nlm.nih.gov/protein/XP_006739055.1 XP_006739055.1]	96.6	98.3	5.13E-130
Condylura cristata	Star-nosed mole	[https://www.ncbi.nlm.nih.gov/protein/XP_004692437.1 XP_004692437.1]	91.0	95.5	3.01E-123
Orcinus orca	Killer whale	[https://www.ncbi.nlm.nih.gov/protein/XP_004286877.2 XP_004286877.2]	88.1	92.3	1.05E-90
Trichechus manatus latirostris	Florida manatee	[https://www.ncbi.nlm.nih.gov/protein/XP_004368376.1 XP_004368376.1]	96.6	98.9	9.95E-131
Alligator mississippiensis	American alligator	[https://www.ncbi.nlm.nih.gov/protein/XP_014457972.1 XP_014457972.1]	69.3	88.6	1.40E-48
Chrysemys picta bellii	Painted turtle	[https://www.ncbi.nlm.nih.gov/protein/XP_005307285.1 XP_005307285.1]	58.3	75	2.18E-78
Gekko japonicus	Schlegel's Japanese gecko	[https://www.ncbi.nlm.nih.gov/protein/XP_015261231.1 XP_015261231.1]	56.5	72.3	4.39E-74
Thamnophis sirtalis	Common garter snake	[https://www.ncbi.nlm.nih.gov/protein/XP_013914711.1 XP_013914711.1]	55.9	69.5	2.75E-69
Xenopus laevis	African clawed frog	[https://www.ncbi.nlm.nih.gov/protein/NP_001088778.1 NP_001088778.1]	55.4	71.2	1.98E-68
Xenopus tropicalis	Western clawed frog	[https://www.ncbi.nlm.nih.gov/protein/NP_001090717.1 NP_001090717.1]	52	71.2	3.57E-65
Callorhinchus milii	Australian ghostshark	[https://www.ncbi.nlm.nih.gov/protein/XP_007888744.1 XP_007888744.1]	39.9	56.8	5.67E-43

= Paralogs =

FANCD2OS has no known paralogs in Homo sapiens.

References

{{cite web|title=FANCD2 opposite strand protein|url=https://www.ncbi.nlm.nih.gov/protein/27735041|publisher=NCBI|accessdate=2 May 2016}}

{{cite web|title=Entrez Gene - FANCD2OS FANCD2 opposite strand Homo sapiens|url=https://www.ncbi.nlm.nih.gov/gene/115795|accessdate=6 February 2016}}

{{cite web|title=Homologene: FANCD2OS|url=https://www.ncbi.nlm.nih.gov/homologene?LinkName=nuccore_homologene&from_uid=27735040|accessdate=6 February 2016}}

{{cite web|title=AceView C3orf24|url=https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&c=gene&q=C3orf24&a=fmol&h=1&vr=v73a|publisher=NCBI|accessdate=2 May 2016}}

{{cite web|title=Conserved Protein Domain Family DUF4563|url=https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi|publisher=NCBI|accessdate=2 May 2016}}

{{cite web|title=NCBI - GDS592 / gnf1m17159_at / Fancd2os|url=https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS592:gnf1m17159_at|publisher=NCBI|accessdate=15 Mar 2016}}