FAT4
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.{{cite web | title = Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79633}}{{cite journal |vauthors=Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y | title = Identification of new human cadherin genes using a combination of protein motif search and gene finding methods | journal = J. Mol. Biol. | volume = 337 | issue = 2 | pages = 307–17 |date=March 2004 | pmid = 15003449 | doi = 10.1016/j.jmb.2004.01.026 }}
FAT4 is associated with the Hippo signaling pathway.{{cite journal |vauthors=Qi C, Zhu YT, Hu L, Zhu YJ |title=Identification of Fat4 as a candidate tumor suppressor gene in breast cancers |journal=Int. J. Cancer |volume=124 |issue=4 |pages=793–8 |date=February 2009 |pmid=19048595 |pmc=2667156 |doi=10.1002/ijc.23775 }}
Clinical significance
Mutations in FAT4 are associated to Hennekam syndrome.{{Cite journal
| pmid = 24913602
| year = 2014
| last1 = Alders
| first1 = M
| title = Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome
| journal = Human Genetics
| last2 = Al-Gazali
| first2 = L
| last3 = Cordeiro
| first3 = I
| last4 = Dallapiccola
| first4 = B
| last5 = Garavelli
| first5 = L
| last6 = Tuysuz
| first6 = B
| last7 = Salehi
| first7 = F
| last8 = Haagmans
| first8 = M. A.
| last9 = Mook
| first9 = O. R.
| last10 = Majoie
| first10 = C. B.
| last11 = Mannens
| first11 = M. M.
| last12 = Hennekam
| first12 = R. C.
| doi = 10.1007/s00439-014-1456-y
| volume=133
| issue = 9
| pages=1161–1167
| s2cid = 14414158
}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Katoh Y, Katoh M |title=Comparative integromics on FAT1, FAT2, FAT3 and FAT4. |journal=Int. J. Mol. Med. |volume=18 |issue= 3 |pages= 523–8 |year= 2006 |pmid= 16865240 |doi= 10.3892/ijmm.18.3.523|doi-access=free }}
- {{cite journal |vauthors=Caporaso N, Gu F, Chatterjee N|title=Genome-wide and candidate gene association study of cigarette smoking behaviors. |journal=PLOS ONE |volume=4 |issue= 2 |pages= e4653 |year= 2009 |pmid= 19247474 |doi= 10.1371/journal.pone.0004653 |editor1-last=Reitsma |editor1-first=Pieter H. |pmc=2644817 |bibcode=2009PLoSO...4.4653C |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Liu Y, Blackwood DH, Caesar S |title=Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder |journal=Molecular Psychiatry |volume= 16|issue= 1|pages= 2–4 |year= 2010 |pmid= 20351715 |doi= 10.1038/mp.2009.107 |display-authors=etal|pmc=3883627}}
- {{cite journal |vauthors=Need AC, Attix DK, McEvoy JM |title=A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB |journal=Hum. Mol. Genet. |volume=18 |issue= 23 |pages= 4650–61 |year= 2009 |pmid= 19734545 |doi= 10.1093/hmg/ddp413 |pmc=2773267 |display-authors=etal}}
- {{cite journal |vauthors=Rose JE, Behm FM, Drgon T |title=Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score |journal=Mol. Med. |volume=16 |issue= 7–8 |pages= 247–53 |year= 2010|pmid= 20379614 |doi= 10.2119/molmed.2009.00159 |pmc=2896464|display-authors=etal}}
- {{cite journal |vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2004 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Johnson AD, Kavousi M, Smith AV |title=Genome-wide association meta-analysis for total serum bilirubin levels |journal=Hum. Mol. Genet. |volume=18 |issue= 14 |pages= 2700–10 |year= 2009 |pmid= 19414484 |doi= 10.1093/hmg/ddp202 |pmc=2701336|display-authors=etal}}
- {{cite journal |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |display-authors=etal|doi-access=free }}
{{refend}}
{{Hippo signaling pathway}}
{{gene-4-stub}}