Login
Login

FBXO2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc}}

{{Infobox_gene}}

F-box only protein 2 is a protein that in humans is encoded by the FBXO2 gene.{{cite journal | vauthors = Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M | title = Identification of a family of human F-box proteins | journal = Curr Biol | volume = 9 | issue = 20 | pages = 1177–9 |date=Dec 1999 | pmid = 10531035 | doi = 10.1016/S0960-9822(00)80020-2 | s2cid = 7467493 | doi-access = free | bibcode = 1999CBio....9.1177C }}{{cite journal | vauthors = Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW | title = A family of mammalian F-box proteins | journal = Curr Biol | volume = 9 | issue = 20 | pages = 1180–2 |date=Dec 1999 | pmid = 10531037 | doi = 10.1016/S0960-9822(00)80021-4 | s2cid = 14341845 | doi-access = free | bibcode = 1999CBio....9.1180W }}{{cite web | title = Entrez Gene: FBXO2 F-box protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26232}}

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors=Erhardt JA, Hynicka W, DiBenedetto A |title=A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35222–7 |year= 1999 |pmid= 9857061 |doi=10.1074/jbc.273.52.35222 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Yoshida Y, Chiba T, Tokunaga F |title=E3 ubiquitin ligase that recognizes sugar chains. |journal=Nature |volume=418 |issue= 6896 |pages= 438–42 |year= 2002 |pmid= 12140560 |doi= 10.1038/nature00890 |bibcode=2002Natur.418..438Y |s2cid=4424996 |display-authors=etal}}
  • {{cite journal | vauthors=Ilyin GP, Sérandour AL, Pigeon C |title=A new subfamily of structurally related human F-box proteins. |journal=Gene |volume=296 |issue= 1–2 |pages= 11–20 |year= 2003 |pmid= 12383498 |doi=10.1016/S0378-1119(02)00867-3 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Eom CY, Lehman IR |title=Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 17 |pages= 9803–7 |year= 2003 |pmid= 12904574 |doi= 10.1073/pnas.1733876100 | pmc=187846 |bibcode=2003PNAS..100.9803E |doi-access=free }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |display-authors=etal|doi-access=free }}

{{refend}}

{{PDB Gallery|geneid=26232}}