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FBXO6

{{Short description|Protein-coding gene in the species Homo sapiens}}

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F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.{{cite journal | vauthors = Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M | title = Identification of a family of human F-box proteins | journal = Curr Biol | volume = 9 | issue = 20 | pages = 1177–9 |date=Dec 1999 | pmid = 10531035 | doi = 10.1016/S0960-9822(00)80020-2 | s2cid = 7467493 | doi-access = free | bibcode = 1999CBio....9.1177C }}{{cite journal | vauthors = Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C | title = cDNA cloning and expression analysis of new members of the mammalian F-box protein family | journal = Genomics | volume = 67 | issue = 1 | pages = 40–7 |date=Nov 2000 | pmid = 10945468 | doi = 10.1006/geno.2000.6211 }}{{cite web | title = Entrez Gene: FBXO6 F-box protein 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26270}}

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.

References

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Further reading

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  • {{cite journal | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Yoshida Y, Tokunaga F, Chiba T |title=Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43877–84 |year= 2003 |pmid= 12939278 |doi= 10.1074/jbc.M304157200 |display-authors=etal|doi-access= free}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ilyin GP, Sérandour AL, Pigeon C |title=A new subfamily of structurally related human F-box proteins. |journal=Gene |volume=296 |issue= 1–2 |pages= 11–20 |year= 2003 |pmid= 12383498 |doi=10.1016/S0378-1119(02)00867-3 |display-authors=etal}}
  • {{cite journal | vauthors=Winston JT, Koepp DM, Zhu C |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4 |s2cid=14341845 |display-authors=etal|doi-access=free |bibcode=1999CBio....9.1180W }}

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