FBXW10
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox gene}}
F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.{{cite journal | vauthors = Kennerson ML, Nassif NT, Nicholson GA | title = Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat | journal = Genomics | volume = 53 | issue = 1 | pages = 110–2 |date=Dec 1998 | pmid = 9787083 | doi = 10.1006/geno.1998.5453 }}{{cite journal | vauthors = Kennerson ML, Gordon MJ, Blair IP, Nicholson GA | title = Single test for two hereditary neuropathies, CMT1A and HNPP | journal = Clin Chem | volume = 41 | issue = 10 | pages = 1534–5 |date=Dec 1995 | pmid = 7586531 | doi = 10.1093/clinchem/41.10.1534| doi-access = free }}{{cite web | title = Entrez Gene: FBXW10 F-box and WD repeat domain containing 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10517}}
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID 20498703).
References
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Further reading
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- {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
- {{cite journal | vauthors=Jin J, Cardozo T, Lovering RC |title=Systematic analysis and nomenclature of mammalian F-box proteins. |journal=Genes Dev. |volume=18 |issue= 21 |pages= 2573–80 |year= 2005 |pmid= 15520277 |doi= 10.1101/gad.1255304 | pmc=525538 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
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