FBXW5
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc|display-authors=6}}
{{Infobox_gene}}
F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.{{cite web | title = Entrez Gene: FBXW5 F-box and WD repeat domain containing 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54461}}
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated Messenger RNA decay candidates, hence not represented. Well established targets of FBXW5 include TSC2{{cite journal | vauthors = Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y | title = WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase | journal = Genes & Development | volume = 22 | issue = 7 | pages = 866–71 | date = April 2008 | pmid = 18381890 | pmc = 2279197 | doi = 10.1101/gad.1624008 }} and SEC23B.{{cite journal | vauthors = Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, Florens L, Washburn MP, Cavasotto CN, Fenyö D, Cuervo AM, Rossi M, Pagano M | title = The ULK1-FBXW5-SEC23B nexus controls autophagy | journal = eLife | volume = 7 | date = December 2018 | pmid = 30596474 | pmc = 6351106 | doi = 10.7554/eLife.42253 | doi-access = free }}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M | title = Identification of a family of human F-box proteins | journal = Current Biology | volume = 9 | issue = 20 | pages = 1177–9 | date = October 1999 | pmid = 10531035 | doi = 10.1016/S0960-9822(00)80020-2 | s2cid = 7467493 | doi-access = free | bibcode = 1999CBio....9.1177C }}
- {{cite journal | vauthors = Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW | title = A family of mammalian F-box proteins | journal = Current Biology | volume = 9 | issue = 20 | pages = 1180–2 | date = October 1999 | pmid = 10531037 | doi = 10.1016/S0960-9822(00)80021-4 | s2cid = 14341845 | doi-access = free | bibcode = 1999CBio....9.1180W }}
- {{cite journal | vauthors = Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H | title = M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 13 | pages = 4419–24 | date = March 2004 | pmid = 15070733 | pmc = 384762 | doi = 10.1073/pnas.0307700101 | bibcode = 2004PNAS..101.4419W | doi-access = free }}
{{refend}}