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FBXW8

{{Short description|Protein-coding gene in humans}}

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F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.{{cite journal | vauthors = Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M | title = Identification of a family of human F-box proteins | journal = Curr Biol | volume = 9 | issue = 20 | pages = 1177–9 |date=Dec 1999 | pmid = 10531035 | doi = 10.1016/S0960-9822(00)80020-2 | s2cid = 7467493 | doi-access = free | bibcode = 1999CBio....9.1177C }}{{cite journal | vauthors = Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW | title = A family of mammalian F-box proteins | journal = Curr Biol | volume = 9 | issue = 20 | pages = 1180–2 |date=Dec 1999 | pmid = 10531037 | doi = 10.1016/S0960-9822(00)80021-4 | s2cid = 14341845 | doi-access = free | bibcode = 1999CBio....9.1180W }}{{cite web | title = Entrez Gene: FBXW8 F-box and WD repeat domain containing 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26259}}

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.{{cite web | title = Entrez Gene: FBXW8 F-box and WD repeat domain containing 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26259}}

References

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Further reading

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  • {{cite journal | vauthors=Tsutsumi T, Kuwabara H, Arai T |title=Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. |journal=Mol. Cell. Biol. |volume=28 |issue= 2 |pages= 743–51 |year= 2008 |pmid= 17998335 |doi= 10.1128/MCB.01665-07 | pmc=2223430 |display-authors=etal}}
  • {{cite journal | vauthors=Koch HB, Zhang R, Verdoodt B |title=Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. |journal=Cell Cycle |volume=6 |issue= 2 |pages= 205–17 |year= 2007 |pmid= 17314511 |doi= 10.4161/cc.6.2.3742|display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Watanabe N, Arai H, Nishihara Y |title=M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 13 |pages= 4419–24 |year= 2004 |pmid= 15070733 |doi= 10.1073/pnas.0307700101 | pmc=384762 |bibcode=2004PNAS..101.4419W |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Dias DC, Dolios G, Wang R, Pan ZQ |title=CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16601–6 |year= 2003 |pmid= 12481031 |doi= 10.1073/pnas.252646399 | pmc=139190 |doi-access=free }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}

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