FCER1G
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide is gamma chain of high affinity IgE receptor. This protein is encoded by the FCER1G gene in humans.{{cite web | title = Entrez Gene: Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | url = https://www.ncbi.nlm.nih.gov/gene/2207 }}
Function
The high affinity IgE receptor, FcεRI, is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008].
References
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Further reading
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- {{cite journal | vauthors = Tsuji M, Ezumi Y, Arai M, Takayama H | title = A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets | journal = The Journal of Biological Chemistry | volume = 272 | issue = 38 | pages = 23528–31 | date = September 1997 | pmid = 9295288 | doi = 10.1074/jbc.272.38.23528 | doi-access = free }}
- {{cite journal | vauthors = Kihara H, Siraganian RP | title = Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor | journal = The Journal of Biological Chemistry | volume = 269 | issue = 35 | pages = 22427–32 | date = September 1994 | doi = 10.1016/S0021-9258(17)31807-0 | pmid = 8071371 | doi-access = free }}
- {{cite journal | vauthors = Huang L, Chen S, Zha X, Yang L, Li B, Yu Z, Wang L, Li Y | title = Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia | journal = Hematology | volume = 17 | issue = 2 | pages = 71–5 | date = March 2012 | pmid = 22664044 | doi = 10.1179/102453312X13221316477895 | s2cid = 24701040 | doi-access = free }}
- {{cite journal | vauthors = Kim YK, Park HW, Yang JS, Oh SY, Chang YS, Shin ES, Lee JE, Kim S, Gho YS, Cho SH, Min KU, Kim YY | title = Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness | journal = Clinical and Experimental Allergy | volume = 37 | issue = 4 | pages = 592–8 | date = April 2007 | pmid = 17430357 | doi = 10.1111/j.1365-2222.2007.02680.x | s2cid = 25869901 }}
- {{cite journal | vauthors = Zha X, Yan X, Shen Q, Zhang Y, Wu X, Chen S, Li B, Yang L, Geng S, Weng J, Du X, Li Y | title = Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia | journal = Journal of Hematology & Oncology | volume = 5 | pages = 74 | date = December 2012 | pmid = 23228155 | pmc = 3544630 | doi = 10.1186/1756-8722-5-74 | doi-access = free }}
- {{cite journal | vauthors = Takahashi K, Hayashi N, Shimokawa T, Umehara N, Kaminogawa S, Ra C | title = Cooperative regulation of Fc receptor gamma-chain gene expression by multiple transcription factors, including Sp1, GABP, and Elf-1 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 22 | pages = 15134–41 | date = May 2008 | pmid = 18378679 | pmc = 3258888 | doi = 10.1074/jbc.M800498200 | doi-access = free }}
- {{cite journal | vauthors = Bao M, Hanabuchi S, Facchinetti V, Du Q, Bover L, Plumas J, Chaperot L, Cao W, Qin J, Sun SC, Liu YJ | title = CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl | journal = Journal of Immunology | volume = 189 | issue = 2 | pages = 786–92 | date = July 2012 | pmid = 22706086 | pmc = 3665352 | doi = 10.4049/jimmunol.1200887 }}
- {{cite journal | vauthors = Gross BS, Melford SK, Watson SP | title = Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets | journal = European Journal of Biochemistry | volume = 263 | issue = 3 | pages = 612–23 | date = August 1999 | pmid = 10469124 | doi = 10.1046/j.1432-1327.1999.00560.x | doi-access = free }}
- {{cite journal | vauthors = Kumar P, Singh B, Lal R, Rembhotkar GW, Singh AB | title = Association between reduced levels of total serum IgE and FcepsilonRI expression in non-releaser basophils | journal = Immunobiology | volume = 214 | issue = 5 | pages = 377–83 | year = 2009 | pmid = 19362683 | doi = 10.1016/j.imbio.2008.09.008 }}
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{{NLM content}}
Category:Genes on human chromosome 1
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