FCGR3A

{{Short description|Mammalian protein found in Homo sapiens}}

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Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene.{{cite journal | vauthors = Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV | title = Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination | journal = Science | volume = 248 | issue = 4956 | pages = 732–5 | date = May 1990 | pmid = 2139735 | doi = 10.1126/science.2139735 | bibcode = 1990Sci...248..732Q }}{{cite web | title = Entrez Gene: FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2214}} It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.

References

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Further reading

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  • {{cite journal | vauthors = Anderson P, Caligiuri M, O'Brien C, Manley T, Ritz J, Schlossman SF | title = Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 6 | pages = 2274–8 | date = March 1990 | pmid = 2138330 | pmc = 53669 | doi = 10.1073/pnas.87.6.2274 | bibcode = 1990PNAS...87.2274A | doi-access = free }}
  • {{cite journal | vauthors = Le Coniat M, Kinet JP, Berger R | title = The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23 | journal = Immunogenetics | volume = 32 | issue = 3 | pages = 183–6 | year = 1990 | pmid = 2146219 | doi = 10.1007/BF02114971 | s2cid = 23874749 }}
  • {{cite journal | vauthors = Ory PA, Clark MR, Kwoh EE, Clarkson SB, Goldstein IM | title = Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils | journal = The Journal of Clinical Investigation | volume = 84 | issue = 5 | pages = 1688–91 | date = November 1989 | pmid = 2478590 | pmc = 304039 | doi = 10.1172/JCI114350 }}
  • {{cite journal | vauthors = Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW | title = Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 3 | pages = 1013–7 | date = February 1989 | pmid = 2521732 | pmc = 286611 | doi = 10.1073/pnas.86.3.1013 | bibcode = 1989PNAS...86.1013P | doi-access = free }}
  • {{cite journal | vauthors = Scallon BJ, Scigliano E, Freedman VH, Miedel MC, Pan YC, Unkeless JC, Kochan JP | title = A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 13 | pages = 5079–83 | date = July 1989 | pmid = 2525780 | pmc = 297560 | doi = 10.1073/pnas.86.13.5079 | bibcode = 1989PNAS...86.5079S | doi-access = free }}
  • {{cite journal | vauthors = Ravetch JV, Perussia B | title = Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions | journal = The Journal of Experimental Medicine | volume = 170 | issue = 2 | pages = 481–97 | date = August 1989 | pmid = 2526846 | pmc = 2189395 | doi = 10.1084/jem.170.2.481 }}
  • {{cite journal | vauthors = Simmons D, Seed B | title = The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein | journal = Nature | volume = 333 | issue = 6173 | pages = 568–70 | date = June 1988 | pmid = 2967436 | doi = 10.1038/333568a0 | bibcode = 1988Natur.333..568S | s2cid = 4351255 }}
  • {{cite journal | vauthors = Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD | title = The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI | journal = Experimental Hematology | volume = 22 | issue = 7 | pages = 599–606 | date = July 1994 | pmid = 7516890 }}
  • {{cite journal | vauthors = Detmers PA, Zhou D, Powell D, Lichenstein H, Kelley M, Pironkova R | title = Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase | journal = Journal of Immunology | volume = 155 | issue = 4 | pages = 2085–95 | date = August 1995 | doi = 10.4049/jimmunol.155.4.2085 | pmid = 7543538 }}
  • {{cite journal | vauthors = Morcos M, Hänsch GM, Schönermark M, Ellwanger S, Härle M, Heckl-Ostreicher B | title = Human glomerular mesangial cells express CD16 and may be stimulated via this receptor | journal = Kidney International | volume = 46 | issue = 6 | pages = 1627–34 | date = December 1994 | pmid = 7700021 | doi = 10.1038/ki.1994.462 | doi-access = free }}
  • {{cite journal | vauthors = Schumann G, Dasgupta JD | title = Specificity of signal transduction through CD16, TCR-CD3 and BCR receptor chains containing the tyrosine-associated activation motif | journal = International Immunology | volume = 6 | issue = 9 | pages = 1383–92 | date = September 1994 | pmid = 7819147 | doi = 10.1093/intimm/6.9.1383 }}
  • {{cite journal | vauthors = Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE | title = The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions | journal = The Journal of Biological Chemistry | volume = 270 | issue = 3 | pages = 1350–61 | date = January 1995 | pmid = 7836402 | doi = 10.1074/jbc.270.3.1350 | doi-access = free}}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Altin JG, Pagler EB, Kinnear BF, Warren HS | title = Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells | journal = Immunology and Cell Biology | volume = 72 | issue = 1 | pages = 87–96 | date = February 1994 | pmid = 8157290 | doi = 10.1038/icb.1994.13 | s2cid = 23222586 }}
  • {{cite journal | vauthors = Pignata C, Prasad KV, Robertson MJ, Levine H, Rudd CE, Ritz J | title = Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells | journal = Journal of Immunology | volume = 151 | issue = 12 | pages = 6794–800 | date = December 1993 | doi = 10.4049/jimmunol.151.12.6794 | pmid = 8258691 }}
  • {{cite journal | vauthors = Cone JC, Lu Y, Trevillyan JM, Bjorndahl JM, Phillips CA | title = Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells | journal = European Journal of Immunology | volume = 23 | issue = 10 | pages = 2488–97 | date = October 1993 | pmid = 8405050 | doi = 10.1002/eji.1830231017 | s2cid = 3112369 }}
  • {{cite journal | vauthors = de Haas M, Koene HR, Kleijer M, de Vries E, Simsek S, van Tol MJ, Roos D, von dem Borne AE | title = A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa | journal = Journal of Immunology | volume = 156 | issue = 8 | pages = 2948–55 | date = April 1996 | doi = 10.4049/jimmunol.156.8.2948 | pmid = 8609432 }}
  • {{cite journal | vauthors = Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE | title = Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene | journal = The Journal of Biological Chemistry | volume = 271 | issue = 48 | pages = 30755–64 | date = November 1996 | pmid = 8940055 | doi = 10.1074/jbc.271.48.30755 | doi-access = free }}
  • {{cite journal | vauthors = Koene HR, Kleijer M, Algra J, Roos D, von dem Borne AE, de Haas M | title = Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype | journal = Blood | volume = 90 | issue = 3 | pages = 1109–14 | date = August 1997 | doi = 10.1182/blood.V90.3.1109 | pmid = 9242542 | doi-access = free }}
  • {{cite journal | vauthors = Nourse JP, Lea R, Crooks P, Wright G, Tran H, Catalano J, Brighton T, Grigg A, Marlton P, Gandhi MK | title = The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms | journal = Blood Coagulation & Fibrinolysis | volume = 23 | issue = 1 | pages = 45–50 | date = January 2012 | pmid = 22024796 | doi = 10.1097/mbc.0b013e32834d7ce3 | s2cid = 3327902 | doi-access = free }}
  • {{cite journal | vauthors = Keane C, Nourse JP, Crooks P, Nguyen-Van D, Mutsando H, Mollee P, Lea RA, Gandhi MK | title = Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma | journal = Internal Medicine Journal | volume = 42 | issue = 10 | pages = 1113–9 | date = October 2012 | pmid = 21883784 | doi = 10.1111/j.1445-5994.2011.02587.x | hdl = 10072/50781 | s2cid = 24913630 | hdl-access = free }}

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