FER (gene)

{{Short description|Protein-coding gene in the species Homo sapiens}}

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.{{cite web | title = Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2241}}

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.

Interactions

FER (gene) has been shown to interact with TMF1{{cite journal |last=Schwartz |first=Y |author2=Ben-Dor I |author3=Navon A |author4=Motro B |author5=Nir U |date=Sep 1998 |title=Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases |journal=FEBS Lett. |volume=434 |issue=3 |pages=339–45 |location = NETHERLANDS| issn = 0014-5793| pmid = 9742951 |doi=10.1016/S0014-5793(98)01003-5 |s2cid=24338520 |doi-access=free }} and Cortactin.{{cite journal |last=Kim |first=L |author2=Wong T W |date=Sep 1998 |title=Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER |journal=J. Biol. Chem. |volume=273 |issue=36 |pages=23542–8 |location = UNITED STATES| issn = 0021-9258| pmid = 9722593 |doi=10.1074/jbc.273.36.23542 |doi-access=free }}

References

{{cite journal | author=Greer P |title=Closing in on the biological functions of Fps/Fes and Fer |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 4 |pages= 278–89 |year= 2002 |pmid= 11994747 |doi= 10.1038/nrm783 |s2cid=22927394 }}
{{cite journal |vauthors=Nishisho I, Nakamura Y, Miyoshi Y |title=Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients |journal=Science |volume=253 |issue= 5020 |pages= 665–9 |year= 1991 |pmid= 1651563 |doi=10.1126/science.1651563 |display-authors=etal|bibcode=1991Sci...253..665N }}
{{cite journal |vauthors=Warrington JA, Hall LV, Hinton LM |title=Radiation hybrid map of 13 loci on the long arm of chromosome 5 |journal=Genomics |volume=11 |issue= 3 |pages= 701–8 |year= 1992 |pmid= 1663488 |doi=10.1016/0888-7543(91)90078-S |display-authors=etal}}
{{cite journal |vauthors=Hao QL, Ferris DK, White G |title=Nuclear and cytoplasmic location of the FER tyrosine kinase |journal=Mol. Cell. Biol. |volume=11 |issue= 2 |pages= 1180–3 |year= 1991 |pmid= 1990274 |doi= 10.1128/mcb.11.2.1180| pmc=359807 |display-authors=etal}}
{{cite journal |vauthors=Krolewski JJ, Lee R, Eddy R |title=Identification and chromosomal mapping of new human tyrosine kinase genes |journal=Oncogene |volume=5 |issue= 3 |pages= 277–82 |year= 1990 |pmid= 2156206 |display-authors=etal}}
{{cite journal |vauthors=Morris C, Heisterkamp N, Hao QL |title=The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q) |journal=Cytogenet. Cell Genet. |volume=53 |issue= 4 |pages= 196–200 |year= 1990 |pmid= 2209086 |doi=10.1159/000132929 |display-authors=etal}}
{{cite journal |vauthors=Pawson T, Letwin K, Lee T |title=The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family |journal=Mol. Cell. Biol. |volume=9 |issue= 12 |pages= 5722–5 |year= 1990 |pmid= 2685575 |doi= 10.1128/mcb.9.12.5722| pmc=363745 |display-authors=etal}}
{{cite journal |vauthors=Hao QL, Heisterkamp N, Groffen J |title=Isolation and sequence analysis of a novel human tyrosine kinase gene |journal=Mol. Cell. Biol. |volume=9 |issue= 4 |pages= 1587–93 |year= 1989 |pmid= 2725517 |doi= 10.1128/mcb.9.4.1587| pmc=362575 }}
{{cite journal |vauthors=Brunati AM, Pinna LA |title=Characterization of four tyrosine protein kinases from the particulate fraction of rat spleen |journal=Eur. J. Biochem. |volume=172 |issue= 2 |pages= 451–7 |year= 1988 |pmid= 3350007 |doi=10.1111/j.1432-1033.1988.tb13909.x |doi-access=free }}
{{cite journal |vauthors=Meggio F, Brunati AM, Pinna LA |title=Polycation-dependent, Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase |journal=FEBS Lett. |volume=215 |issue= 2 |pages= 241–6 |year= 1987 |pmid= 3472906 |doi=10.1016/0014-5793(87)80154-0 |s2cid=2801487 |doi-access=free }}
{{cite journal |vauthors=Kim L, Wong TW |title=The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors |journal=Mol. Cell. Biol. |volume=15 |issue= 8 |pages= 4553–61 |year= 1995 |pmid= 7623846 |doi= 10.1128/mcb.15.8.4553| pmc=230695 }}
{{cite journal |vauthors=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes |journal=Oncogene |volume=8 |issue= 12 |pages= 3403–10 |year= 1993 |pmid= 8247543 }}
{{cite journal |vauthors=Kim L, Wong TW |title=Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23542–8 |year= 1998 |pmid= 9722593 |doi=10.1074/jbc.273.36.23542 |doi-access=free }}
{{cite journal |vauthors=Rosato R, Veltmaat JM, Groffen J, Heisterkamp N |title=Involvement of the tyrosine kinase fer in cell adhesion |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5762–70 |year= 1998 |pmid= 9742093 |doi= 10.1128/mcb.18.10.5762| pmc=109162 }}
{{cite journal |vauthors=Schwartz Y, Ben-Dor I, Navon A |title=Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases |journal=FEBS Lett. |volume=434 |issue= 3 |pages= 339–45 |year= 1998 |pmid= 9742951 |doi=10.1016/S0014-5793(98)01003-5 |s2cid=24338520 |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Huang C, Liu J, Haudenschild CC, Zhan X |title=The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25770–6 |year= 1998 |pmid= 9748248 |doi=10.1074/jbc.273.40.25770 |doi-access=free }}
{{cite journal |vauthors=Corti C, Leclerc L'Hostis E, Quadroni M |title=Tyrosine phosphorylation modulates the interaction of calmodulin with its target proteins |journal=Eur. J. Biochem. |volume=262 |issue= 3 |pages= 790–802 |year= 1999 |pmid= 10411641 |doi=10.1046/j.1432-1327.1999.00441.x |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Priel-Halachmi S, Ben-Dor I, Shpungin S |title=FER kinase activation of Stat3 is determined by the N-terminal sequence |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28902–10 |year= 2000 |pmid= 10878010 |doi= 10.1074/jbc.M003402200 |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Kapus A, Di Ciano C, Sun J |title=Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32289–98 |year= 2000 |pmid= 10921917 |doi= 10.1074/jbc.M003172200 |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Orlovsky K, Ben-Dor I, Priel-Halachmi S |title=N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo |journal=Biochemistry |volume=39 |issue= 36 |pages= 11084–91 |year= 2000 |pmid= 10998246 |doi=10.1021/bi0005153 |display-authors=etal}}

Category:Tyrosine kinases

FER (gene)

Interactions

References

Further reading