FEZ2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene.{{cite journal |vauthors=Bloom L, Horvitz HR | title = The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 7 | pages = 3414–9 |date=May 1997 | pmid = 9096408 | pmc = 20384 | doi =10.1073/pnas.94.7.3414 | bibcode =1997PNAS...94.3414B | doi-access = free }}{{cite web | title = Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9637}}
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.
Interactions
FEZ2 has been shown to interact with Protein kinase Mζ.{{cite journal |doi=10.1016/j.bbrc.2003.12.006 |last=Fujita |first=Toshitsugu |author2=Ikuta Junko |author3=Hamada Juri |author4=Okajima Toshihide |author5=Tatematsu Kenji |author6=Tanizawa Katsuyuki |author7=Kuroda Shun'ichi |date=Jan 2004 |title=Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1 |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue=3 |pages=738–44 |location = United States| issn = 0006-291X| pmid = 14697253 }}
References
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Further reading
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- {{cite journal |vauthors=Ranes-Goldberg MG, Hori T, Mohan-Peterson S, Spits H |title=Identification of human pre-T/NK cell-associated genes |journal=J. Immunol. |volume=151 |issue= 10 |pages= 5810–21 |year= 1993 |doi=10.4049/jimmunol.151.10.5810 |pmid= 8228263 |s2cid=39286195 }}
- {{cite journal |vauthors=Kolle G, Georgas K, Holmes GP |title=CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis |journal=Mech. Dev. |volume=90 |issue= 2 |pages= 181–93 |year= 2000 |pmid= 10642437 |doi=10.1016/S0925-4773(99)00248-8 |s2cid=6529349 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |display-authors=etal|bibcode=2000PNAS...97.9543H |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Surpili MJ, Delben TM, Kobarg J |title=Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1 |journal=Biochemistry |volume=42 |issue= 51 |pages= 15369–76 |year= 2004 |pmid= 14690447 |doi= 10.1021/bi034575v }}
- {{cite journal |vauthors=Fujita T, Ikuta J, Hamada J |title=Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1 |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 738–44 |year= 2004 |pmid= 14697253 |doi=10.1016/j.bbrc.2003.12.006 |display-authors=etal}}
- {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal|bibcode=2005Natur.434..724H |doi-access=free }}
- {{cite journal |vauthors=Assmann EM, Alborghetti MR, Camargo ME, Kobarg J |title=FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 9869–81 |year= 2006 |pmid= 16484223 |doi= 10.1074/jbc.M513280200 |doi-access= free }}
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