FGF-1 internal ribosome entry site (IRES)

{{Short description|RNA element}}

{{Infobox rfam

| Name = FGF-1 internal ribosome entry site (IRES)

| image = RF00387.jpg

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| caption = Predicted secondary structure and sequence conservation of IRES_FGF1

| Symbol = IRES_FGF1

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| Rfam = RF00387

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| RNA_type = Cis-reg; IRES

| Tax_domain = Eukaryota

| GO = {{GO|0043022}}

| SO = {{SO|0000243}}

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The FGF-1 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor 1 and allows cap-independent translation. It is thought that FGF-1 internal ribosome entry site (IRES) activity is strictly controlled and highly tissue specific.{{cite journal | vauthors = Martineau Y, Le Bec C, Monbrun L, Allo V, Chiu IM, Danos O, Moine H, Prats H, Prats AC | title = Internal ribosome entry site structural motifs conserved among mammalian fibroblast growth factor 1 alternatively spliced mRNAs | journal = Molecular and Cellular Biology | volume = 24 | issue = 17 | pages = 7622–7635 | date = September 2004 | pmid = 15314170 | pmc = 507008 | doi = 10.1128/MCB.24.17.7622-7635.2004 }}