FIBP
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.{{cite journal |last1=Kolpakova |first1=E |last2=Wiedłocha |first2=A |last3=Stenmark |first3=H |last4=Klingenberg |first4=O |last5=Faines|first5=PO|last6=Olsnes|first6=S|date=15 November 1998 |title=Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor |journal=Biochem. J. |volume=336 |issue=1|pages=213–22 |pmid = 9806903| pmc = 1219860|doi=10.1042/bj3360213}}{{cite web |title=Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein |url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9158 |website=ncbi.nlm.nih.gov}}
Function
Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.
Interactions
References
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Further reading
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- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = Kolpakova E, Frengen E, Stokke T, Olsnes S | title = Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein | journal = Biochem. J. | volume = 352 | issue = 3 | pages = 629–35 | year = 2000 | pmid = 11104667 | pmc = 1221498 | doi = 10.1042/0264-6021:3520629 }}
- {{cite journal | vauthors = Tassi E, Al-Attar A, Aigner A, Swift MR, McDonnell K, Karavanov A, Wellstein A | title = Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein | journal = J. Biol. Chem. | volume = 276 | issue = 43 | pages = 40247–53 | year = 2001 | pmid = 11509569 | doi = 10.1074/jbc.M104933200 | doi-access = free }}
- {{cite journal | vauthors = Skjerpen CS, Nilsen T, Wesche J, Olsnes S | title = Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity | journal = EMBO J. | volume = 21 | issue = 15 | pages = 4058–69 | year = 2002 | pmid = 12145206 | pmc = 126148 | doi = 10.1093/emboj/cdf402 }}
- {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
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