FKBP2

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.

FKBP2 has been shown to interact with ARFGEF1{{cite journal | vauthors = Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M | title = Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 5 | pages = 2322–7 | date = Mar 2003 | pmid = 12606707 | pmc = 151339 | doi = 10.1073/pnas.2628047100 | bibcode = 2003PNAS..100.2322P | doi-access = free }} and EPB41L2.{{cite journal | vauthors = Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH | title = The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1 | journal = J. Cell Biol. | volume = 141 | issue = 1 | pages = 143–53 | date = Apr 1998 | pmid = 9531554 | pmc = 2132710 | doi = 10.1083/jcb.141.1.143 }}

{{Reflist}}

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• {{cite journal | vauthors = DiLella AG, Hawkins A, Craig RJ, Schreiber SL, Griffin CA | title = Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13 | journal = Biochem. Biophys. Res. Commun. | volume = 189 | issue = 2 | pages = 819–23 | year = 1992 | pmid = 1281998 | doi = 10.1016/0006-291X(92)92276-4 }}
• {{cite journal | vauthors = Hendrickson BA, Zhang W, Craig RJ, Jin YJ, Bierer BE, Burakoff S, DiLella AG | title = Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1 | journal = Gene | volume = 134 | issue = 2 | pages = 271–5 | year = 1993 | pmid = 7505249 | doi = 10.1016/0378-1119(93)90106-D }}
• {{cite journal | vauthors = Bush KT, Hendrickson BA, Nigam SK | title = Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum | journal = Biochem. J. | volume = 303 | issue = Pt 3 | pages = 705–8 | year = 1994 | pmid = 7526846 | pmc = 1137603 | doi = 10.1042/bj3030705}}
• {{cite journal | vauthors = Nigam SK, Jin YJ, Jin MJ, Bush KT, Bierer BE, Burakoff SJ | title = Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum | journal = Biochem. J. | volume = 294 | issue = Pt 2 | pages = 511–5 | year = 1993 | pmid = 8373365 | pmc = 1134484 | doi = 10.1042/bj2940511}}
• {{cite journal | vauthors = Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH | title = The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1 | journal = J. Cell Biol. | volume = 141 | issue = 1 | pages = 143–53 | year = 1998 | pmid = 9531554 | pmc = 2132710 | doi = 10.1083/jcb.141.1.143 }}
• {{cite journal | vauthors = Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M | title = Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 5 | pages = 2322–7 | year = 2003 | pmid = 12606707 | pmc = 151339 | doi = 10.1073/pnas.2628047100 | bibcode = 2003PNAS..100.2322P | doi-access = free }}
• {{cite journal | vauthors = Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ | title = Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein | journal = Science | volume = 302 | issue = 5651 | pages = 1769–72 | year = 2003 | pmid = 14657499 | doi = 10.1126/science.1090389 | bibcode = 2003Sci...302.1769W | s2cid = 43221047 }}
• {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
• {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY|authorlink13=Huda Zoghbi | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 |s2cid=13709685 | doi-access = free }}

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Category:EC 5.2.1

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