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FKBP8

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene.{{cite journal |vauthors=Lam E, Martin M, Wiederrecht G | title = Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs | journal = Gene | volume = 160 | issue = 2 | pages = 297–302 |date=Sep 1995 | pmid = 7543869 | doi =10.1016/0378-1119(95)00216-S }}{{cite web | title = Entrez Gene: FKBP8 FK506 binding protein 8, 38kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23770}}

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.

References

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Further reading

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  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal |vauthors=Pedersen KM, Finsen B, Celis JE, Jensen NA |title=muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo. |journal=Electrophoresis |volume=20 |issue= 2 |pages= 249–55 |year= 1999 |pmid= 10197430 |doi= 10.1002/(SICI)1522-2683(19990201)20:2<249::AID-ELPS249>3.0.CO;2-F |s2cid=23007045 }}
  • {{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
  • {{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Shirane M, Nakayama KI |title=Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. |journal=Nat. Cell Biol. |volume=5 |issue= 1 |pages= 28–37 |year= 2003 |pmid= 12510191 |doi= 10.1038/ncb894 |s2cid=11653096 }}
  • {{cite journal |vauthors=Rosner M, Hofer K, Kubista M, Hengstschläger M |title=Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38. |journal=Oncogene |volume=22 |issue= 31 |pages= 4786–98 |year= 2003 |pmid= 12894220 |doi= 10.1038/sj.onc.1206776 |doi-access= free }}
  • {{cite journal |vauthors=Grimwood J, Gordon LA, Olsen A |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Bulgakov OV, Eggenschwiler JT, Hong DH |title=FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. |journal=Development |volume=131 |issue= 9 |pages= 2149–59 |year= 2004 |pmid= 15105374 |doi= 10.1242/dev.01122 |s2cid=8203913 |display-authors=etal|doi-access= }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal |vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |display-authors=etal}}
  • {{cite journal |vauthors=Rush J, Moritz A, Lee KA |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |s2cid=7200157 |display-authors=etal}}
  • {{cite journal |vauthors=Kang CB, Tai J, Chia J, Yoon HS |title=The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38). |journal=FEBS Lett. |volume=579 |issue= 6 |pages= 1469–76 |year= 2005 |pmid= 15733859 |doi= 10.1016/j.febslet.2005.01.053 |s2cid=19114701 |doi-access=free |hdl=10356/95126 |hdl-access=free }}
  • {{cite journal |vauthors=Weiwad M, Edlich F, Erdmann F |title=A reassessment of the inhibitory capacity of human FKBP38 on calcineurin. |journal=FEBS Lett. |volume=579 |issue= 7 |pages= 1591–6 |year= 2005 |pmid= 15757646 |doi= 10.1016/j.febslet.2004.12.098 |s2cid=12995306 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Edlich F, Weiwad M, Erdmann F |title=Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin. |journal=EMBO J. |volume=24 |issue= 14 |pages= 2688–99 |year= 2005 |pmid= 15990872 |doi= 10.1038/sj.emboj.7600739 | pmc=1176465 |display-authors=etal}}
  • {{cite journal |vauthors=Kang CB, Feng L, Chia J, Yoon HS |title=Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 1 |pages= 30–8 |year= 2005 |pmid= 16176796 |doi= 10.1016/j.bbrc.2005.09.023 |hdl=10356/94816 |hdl-access=free }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
  • {{cite journal |vauthors=Oh JH, Yang JO, Hahn Y |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |s2cid=69278 |display-authors=etal}}
  • {{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |display-authors=etal}}

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{{PDB Gallery|geneid=23770}}

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{{Enzymes}}

{{Portal bar|Biology|border=no}}

Category:EC 5.2.1

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