FLOT1

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{{Short description|Protein-coding gene in the species Homo sapiens}}

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Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.{{cite web | title = Entrez Gene: FLOT1 flotillin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10211| accessdate = }}

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.{{cite journal |vauthors=Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF | title = Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins | journal = J. Biol. Chem. | volume = 272 | issue = 21 | pages = 13793–802 |date=May 1997 | pmid = 9153235 | doi = 10.1074/jbc.272.21.13793 | doi-access = free }} The function of flotillin 1 has not been determined.

Interactions

FLOT1 has been shown to interact with SORBS1.{{cite journal |vauthors=Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I | title = Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites | journal = J. Cell Sci. | volume = 117 | issue = Pt 12 | pages = 2557–68 |date=May 2004 | pmid = 15128873 | doi = 10.1242/jcs.01148 | s2cid = 14083271 | doi-access = }}{{cite journal |vauthors=Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR | title = CAP defines a second signalling pathway required for insulin-stimulated glucose transport | journal = Nature | volume = 407 | issue = 6801 | pages = 202–7 |date=September 2000 | pmid = 11001060 | doi = 10.1038/35025089 | url = https://deepblue.lib.umich.edu/bitstream/2027.42/62940/1/407202a0.pdf | bibcode = 2000Natur.407..202B | hdl = 2027.42/62940 | s2cid = 4334519 | hdl-access = free }}{{cite journal |vauthors=Kimura A, Baumann CA, Chiang SH, Saltiel AR | title = The sorbin homology domain: a motif for the targeting of proteins to lipid rafts | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 16 | pages = 9098–103 |date=July 2001 | pmid = 11481476 | pmc = 55379 | doi = 10.1073/pnas.151252898 | bibcode = 2001PNAS...98.9098K | doi-access = free }}

References

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Further reading

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  • {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
  • {{cite journal |vauthors=Volonte D, Galbiati F, Li S |title=Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12702–9 |year= 1999 |pmid= 10212252 |doi=10.1074/jbc.274.18.12702 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Hazarika P, Dham N, Patel P |title=Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. |journal=J. Cell. Biochem. |volume=75 |issue= 1 |pages= 147–59 |year= 1999 |pmid= 10462713 |doi=10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D |s2cid=12223151 |display-authors=etal}}
  • {{cite journal |vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |display-authors=etal|bibcode=2000PNAS...97.9543H |doi-access=free }}
  • {{cite journal |vauthors=Baumann CA, Ribon V, Kanzaki M |title=CAP defines a second signalling pathway required for insulin-stimulated glucose transport. |journal=Nature |volume=407 |issue= 6801 |pages= 202–7 |year= 2000 |pmid= 11001060 |doi= 10.1038/35025089 |display-authors=etal|bibcode=2000Natur.407..202B |hdl=2027.42/62940 |s2cid=4334519 |url=https://deepblue.lib.umich.edu/bitstream/2027.42/62940/1/407202a0.pdf |hdl-access=free }}
  • {{cite journal |vauthors=Zhang QH, Ye M, Wu XY |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 |display-authors=etal}}
  • {{cite journal |vauthors=Salzer U, Prohaska R |title=Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. |journal=Blood |volume=97 |issue= 4 |pages= 1141–3 |year= 2001 |pmid= 11159550 |doi=10.1182/blood.V97.4.1141 }}
  • {{cite journal |vauthors=Edgar AJ, Polak JM |title=Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 1 |pages= 53–64 |year= 2001 |pmid= 11167132 |doi=10.1016/S1357-2725(00)00069-8 }}
  • {{cite journal |vauthors=Kimura A, Baumann CA, Chiang SH, Saltiel AR |title=The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 9098–103 |year= 2001 |pmid= 11481476 |doi= 10.1073/pnas.151252898 | pmc=55379 |bibcode=2001PNAS...98.9098K |doi-access=free }}
  • {{cite journal |vauthors=Stuermer CA, Lang DM, Kirsch F |title=Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2. |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3031–45 |year= 2002 |pmid= 11598189 |doi= 10.1091/mbc.12.10.3031| pmc=60153 |display-authors=etal}}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal |bibcode=2002PNAS...9916899M|doi-access=free }}
  • {{cite journal |vauthors=Girardot N, Allinquant B, Duyckaerts C |title=[Lipid rafts, flotillin-1 and Alzheimer disease] |journal=J. Soc. Biol. |volume=197 |issue= 3 |pages= 223–9 |year= 2004 |pmid= 14708344 |doi= 10.1051/jbio/2003197030223|s2cid=86221484 }}
  • {{cite journal |vauthors=Wakasugi K, Nakano T, Kitatsuji C, Morishima I |title=Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. |journal=Biochem. Biophys. Res. Commun. |volume=318 |issue= 2 |pages= 453–60 |year= 2004 |pmid= 15120622 |doi= 10.1016/j.bbrc.2004.04.045 }}
  • {{cite journal |vauthors=Haglund K, Ivankovic-Dikic I, Shimokawa N |title=Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. |journal=J. Cell Sci. |volume=117 |issue= Pt 12 |pages= 2557–68 |year= 2004 |pmid= 15128873 |doi= 10.1242/jcs.01148 |s2cid=14083271 |display-authors=etal|doi-access= }}
  • {{cite journal |vauthors=Bared SM, Buechler C, Boettcher A |title=Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5399–407 |year= 2005 |pmid= 15469992 |doi= 10.1091/mbc.E04-03-0182 | pmc=532019 |display-authors=etal}}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal |vauthors=Jacobowitz DM, Kallarakal AT |title=Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain. |journal=Neurotoxicity Research |volume=6 |issue= 4 |pages= 245–57 |year= 2005 |pmid= 15545008 |doi=10.1007/BF03033435 |s2cid=22168131 }}
  • {{cite journal |vauthors=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1–3 |pages= 203–8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007 |s2cid=9746088 }}
  • {{cite journal |vauthors=Glebov OO, Bright NA, Nichols BJ |title=Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. |journal=Nat. Cell Biol.|volume=8 |issue= 1 |pages= 46–54 |year= 2006 |pmid= 16341206 |doi=10.1038/ncb1342 |s2cid=36695735 }}

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