FLT4

FLT4 has been shown to interact with SHC1.{{cite journal | vauthors = Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K | title = Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors | journal = Oncogene | volume = 9 | issue = 12 | pages = 3545–55 | date = December 1994 | pmid = 7970715 }}{{cite journal | vauthors = Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP | title = Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling | journal = Oncogene | volume = 18 | issue = 2 | pages = 507–14 | date = January 1999 | pmid = 9927207 | doi = 10.1038/sj.onc.1202315 | doi-access = free }}{{cite journal | vauthors = Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP | title = Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase | journal = The Journal of Biological Chemistry | volume = 271 | issue = 22 | pages = 12956–63 | date = May 1996 | pmid = 8662748 | doi = 10.1074/jbc.271.22.12956 | doi-access = free }}

• VEGF receptors

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• {{cite journal | vauthors = Petrova TV, Makinen T, Alitalo K | title = Signaling via vascular endothelial growth factor receptors | journal = Experimental Cell Research | volume = 253 | issue = 1 | pages = 117–30 | date = November 1999 | pmid = 10579917 | doi = 10.1006/excr.1999.4707 }}
• {{cite journal | vauthors = Aprelikova O, Pajusola K, Partanen J, Armstrong E, Alitalo R, Bailey SK, McMahon J, Wasmuth J, Huebner K, Alitalo K | title = FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter | journal = Cancer Research | volume = 52 | issue = 3 | pages = 746–8 | date = February 1992 | pmid = 1310071 }}
• {{cite journal | vauthors = Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D | title = Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene | journal = Genomics | volume = 13 | issue = 2 | pages = 475–8 | date = June 1992 | pmid = 1319394 | doi = 10.1016/0888-7543(92)90277-Y }}
• {{cite journal | vauthors = Pajusola K, Aprelikova O, Korhonen J, Kaipainen A, Pertovaara L, Alitalo R, Alitalo K | title = FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines | journal = Cancer Research | volume = 52 | issue = 20 | pages = 5738–43 | date = October 1992 | pmid = 1327515 }}
• {{cite journal | vauthors = Fournier E, Dubreuil P, Birnbaum D, Borg JP | title = Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor | journal = Oncogene | volume = 11 | issue = 5 | pages = 921–31 | date = September 1995 | pmid = 7675451 }}
• {{cite journal | vauthors = Pajusola K, Aprelikova O, Armstrong E, Morris S, Alitalo K | title = Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts | journal = Oncogene | volume = 8 | issue = 11 | pages = 2931–7 | date = November 1993 | pmid = 7692369 }}
• {{cite journal | vauthors = Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K | title = Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors | journal = Oncogene | volume = 9 | issue = 12 | pages = 3545–55 | date = December 1994 | pmid = 7970715 }}
• {{cite journal | vauthors = Galland F, Karamysheva A, Pebusque MJ, Borg JP, Rottapel R, Dubreuil P, Rosnet O, Birnbaum D | title = The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor | journal = Oncogene | volume = 8 | issue = 5 | pages = 1233–40 | date = May 1993 | pmid = 8386825 }}
• {{cite journal | vauthors = Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP | title = Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase | journal = The Journal of Biological Chemistry | volume = 271 | issue = 22 | pages = 12956–63 | date = May 1996 | pmid = 8662748 | doi = 10.1074/jbc.271.22.12956 | doi-access = free }}
• {{cite journal | vauthors = Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI | title = Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 5 | pages = 1988–92 | date = March 1996 | pmid = 8700872 | pmc = 39896 | doi = 10.1073/pnas.93.5.1988 | bibcode = 1996PNAS...93.1988L | doi-access = free }}
• {{cite journal | vauthors = Kukk E, Lymboussaki A, Taira S, Kaipainen A, Jeltsch M, Joukov V, Alitalo K | title = VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development | journal = Development | volume = 122 | issue = 12 | pages = 3829–37 | date = December 1996 | doi = 10.1242/dev.122.12.3829 | pmid = 9012504 }}
• {{cite journal | vauthors = Achen MG, Jeltsch M, Kukk E, Mäkinen T, Vitali A, Wilks AF, Alitalo K, Stacker SA | title = Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 2 | pages = 548–53 | date = January 1998 | pmid = 9435229 | pmc = 18457 | doi = 10.1073/pnas.95.2.548 | bibcode = 1998PNAS...95..548A | doi-access = free }}
• {{cite journal | vauthors = Ferrell RE, Levinson KL, Esman JH, Kimak MA, Lawrence EC, Barmada MM, Finegold DN | title = Hereditary lymphedema: evidence for linkage and genetic heterogeneity | journal = Human Molecular Genetics | volume = 7 | issue = 13 | pages = 2073–8 | date = December 1998 | pmid = 9817924 | doi = 10.1093/hmg/7.13.2073 | doi-access = }}
• {{cite journal | vauthors = Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP | title = Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling | journal = Oncogene | volume = 18 | issue = 2 | pages = 507–14 | date = January 1999 | pmid = 9927207 | doi = 10.1038/sj.onc.1202315 | doi-access = free }}
• {{cite journal | vauthors = Karkkainen MJ, Ferrell RE, Lawrence EC, Kimak MA, Levinson KL, McTigue MA, Alitalo K, Finegold DN | title = Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema | journal = Nature Genetics | volume = 25 | issue = 2 | pages = 153–9 | date = June 2000 | pmid = 10835628 | doi = 10.1038/75997 | s2cid = 38445644 }}
• {{cite journal | vauthors = Irrthum A, Karkkainen MJ, Devriendt K, Alitalo K, Vikkula M | title = Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase | journal = American Journal of Human Genetics | volume = 67 | issue = 2 | pages = 295–301 | date = August 2000 | pmid = 10856194 | pmc = 1287178 | doi = 10.1086/303019 }}
• {{cite journal | vauthors = Wang JF, Zhang XF, Groopman JE | title = Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 41950–7 | date = November 2001 | pmid = 11553610 | doi = 10.1074/jbc.M101370200 | doi-access = free }}
• {{cite journal | vauthors = Baldwin ME, Roufail S, Halford MM, Alitalo K, Stacker SA, Achen MG | title = Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis | journal = The Journal of Biological Chemistry | volume = 276 | issue = 47 | pages = 44307–14 | date = November 2001 | pmid = 11574540 | doi = 10.1074/jbc.M106188200 | doi-access = free}}
• {{cite journal | vauthors = Walter JW, North PE, Waner M, Mizeracki A, Blei F, Walker JW, Reinisch JF, Marchuk DA | title = Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma | journal = Genes, Chromosomes & Cancer | volume = 33 | issue = 3 | pages = 295–303 | date = March 2002 | pmid = 11807987 | doi = 10.1002/gcc.10028 | s2cid = 33428561 }}

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• [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=milroy GeneReviews/NCBI/NIH/UW entry on Milroy Disease]

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{{Growth factor receptors}}

{{Tyrosine kinases}}

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Category:Tyrosine kinase receptors

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