FOSL2

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355}}

• AP-1 (transcription factor)

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• {{cite journal | vauthors = Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R | title = Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation | journal = Oncogene | volume = 5 | issue = 3 | pages = 249–55 | date = March 1990 | pmid = 2107490 }}
• {{cite journal | vauthors = Molven A, Houge G, Berger R | title = Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23 | journal = Genomics | volume = 38 | issue = 1 | pages = 72–5 | date = November 1996 | pmid = 8954781 | doi = 10.1006/geno.1996.0593 }}
• {{cite journal | vauthors = Outinen PA, Sood SK, Pfeifer SI, Pamidi S, Podor TJ, Li J, Weitz JI, Austin RC | title = Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells | journal = Blood | volume = 94 | issue = 3 | pages = 959–67 | date = August 1999 | pmid = 10419887 | doi = 10.1182/blood.V94.3.959.415k20_959_967}}
• {{cite journal | vauthors = Miyamoto NG, Medberry PS, Hesselgesser J, Boehlk S, Nelson PJ, Krensky AM, Perez HD | title = Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors | journal = Journal of Neuroimmunology | volume = 105 | issue = 1 | pages = 78–90 | date = June 2000 | pmid = 10713367 | doi = 10.1016/S0165-5728(00)00195-8 | s2cid = 8547340 }}
• {{cite journal | vauthors = Ng DC, Shafaee S, Lee D, Bikle DD | title = Requirement of an AP-1 site in the calcium response region of the involucrin promoter | journal = The Journal of Biological Chemistry | volume = 275 | issue = 31 | pages = 24080–8 | date = August 2000 | pmid = 10816578 | doi = 10.1074/jbc.M002508200 | doi-access = free }}
• {{cite journal | vauthors = Bamberger AM, Milde-Langosch K, Rössing E, Goemann C, Löning T | title = Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators | journal = Journal of Cancer Research and Clinical Oncology | volume = 127 | issue = 9 | pages = 545–50 | date = September 2001 | pmid = 11570575 | doi = 10.1007/s004320100255 | s2cid = 7184971 }}
• {{cite journal | vauthors = Udalova IA, Kwiatkowski D | title = Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region | journal = Biochemical and Biophysical Research Communications | volume = 289 | issue = 1 | pages = 25–33 | date = November 2001 | pmid = 11708771 | doi = 10.1006/bbrc.2001.5929 }}
• {{cite journal | vauthors = Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P | title = Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter | journal = Molecular and Cellular Biology | volume = 22 | issue = 13 | pages = 4522–34 | date = July 2002 | pmid = 12052862 | pmc = 133906 | doi = 10.1128/MCB.22.13.4522-4534.2002 }}
• {{cite journal | vauthors = Santalucía T, Christmann M, Yacoub MH, Brand NJ | title = Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1 | journal = Cardiovascular Research | volume = 59 | issue = 3 | pages = 639–48 | date = September 2003 | pmid = 14499865 | doi = 10.1016/S0008-6363(03)00472-3 | doi-access = free }}
• {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }}
• {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

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• {{MeshName|FOSL2+protein,+human}}
• {{FactorBook|FOSL2}}

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{{Transcription factors|g1}}

Category:Transcription factors

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