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FOXK2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.{{cite journal | vauthors = Durand DB, Shaw JP, Bush MR, Replogle RE, Belagaje R, Crabtree GR | title = Characterization of antigen receptor response elements within the interleukin-2 enhancer | journal = Mol Cell Biol | volume = 8 | issue = 4 | pages = 1715–24 |date=Jul 1988 | pmid = 3260003 | pmc = 363332 | doi = 10.1128/MCB.8.4.1715}}{{cite web | title = Entrez Gene: FOXK2 forkhead box K2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3607}}

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.

References

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Further reading

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  • {{cite journal | vauthors=Li C, Lusis AJ, Sparkes R |title=Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF. |journal=Genomics |volume=13 |issue= 3 |pages= 665–71 |year= 1992 |pmid= 1339390 |doi=10.1016/0888-7543(92)90139-J |display-authors=etal}}
  • {{cite journal | vauthors=Li C, Lai CF, Sigman DS, Gaynor RB|author4-link=Richard Gaynor |title=Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7739–43 |year= 1991 |pmid= 1909027 |doi=10.1073/pnas.88.17.7739 | pmc=52378 |bibcode=1991PNAS...88.7739L |doi-access=free }}
  • {{cite journal | vauthors=Nirula A, Moore DJ, Gaynor RB |title=Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter. |journal=J. Biol. Chem. |volume=272 |issue= 12 |pages= 7736–45 |year= 1997 |pmid= 9065434 |doi=10.1074/jbc.272.12.7736 |doi-access=free }}
  • {{cite journal | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
  • {{cite journal | vauthors=Liu PP, Chen YC, Li C |title=Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a). |journal=Proteins |volume=49 |issue= 4 |pages= 543–53 |year= 2003 |pmid= 12402362 |doi= 10.1002/prot.10227 |s2cid=1142924 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Tsai KL, Huang CY, Chang CH |title=Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins. |journal=J. Biol. Chem. |volume=281 |issue= 25 |pages= 17400–9 |year= 2006 |pmid= 16624804 |doi= 10.1074/jbc.M600478200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Zody MC, Garber M, Adams DJ |title=DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |journal=Nature |volume=440 |issue= 7087 |pages= 1045–9 |year= 2006 |pmid= 16625196 |doi= 10.1038/nature04689 | pmc=2610434 |bibcode=2006Natur.440.1045Z |display-authors=etal}}
  • {{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}}

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External links

  • {{MeshName|FOXK2+protein,+human}}
  • {{PDBe-KB2|Q01167|Forkhead box protein K2}}

{{NLM content}}

{{PDB Gallery|geneid=3607}}

{{Transcription factors|g3}}

Category:Forkhead transcription factors

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