FOXN1

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. In the chick embryo, the FOXN1 gene is expressed in the developing thymus, claws and feathers. The expression of FOXN1 in feathers and claws indicates that it may regulate the feather outgrowth. In feather and claws, FOXN1 can potentially regulate expression of keratins similar to mammalian orthologs. {{cite journal | vauthors = Darnell DK, Zhang LS, Hannenhalli S, Yaklichkin SY | title = Developmental expression of chicken FOXN1 and putative target genes during feather development | journal = The International Journal of Developmental Biology | volume = 58 | issue = 1 | pages = 57–64 | date = Dec 2014 | pmid = 24860996 | doi = 10.1387/ijdb.130023sy | doi-access = free }} In thymic epithelial cells, FOXN1 has been shown to bind to and regulate genes involved in T-cell maturation and antigen presentation.{{cite journal | vauthors = Žuklys S, Handel A, Zhanybekova S, Govani F, Keller M, Maio S, Mayer CE, Teh HY, Hafen K, Gallone G, Barthlott T, Ponting CP, Holländer GA | title = Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells | journal = Nature Immunology | volume = 17 | issue = 10 | pages = 1206–15 | date = Aug 2016 | pmid = 27548434 | doi = 10.1038/ni.3537 | pmc = 5033077 }}

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• {{cite journal | vauthors = Zhang Z, Burnley P, Coder B, Su DM | title = Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis | journal = International Journal of Biological Sciences | volume = 8 | issue = 8 | pages = 1156–67 | year = 2012 | pmid = 23091413 | pmc = 3477685 | doi = 10.7150/ijbs.5033 }}
• {{cite journal | vauthors = Mecklenburg L, Tychsen B, Paus R | title = Learning from nudity: lessons from the nude phenotype | journal = Experimental Dermatology | volume = 14 | issue = 11 | pages = 797–810 | date = Nov 2005 | pmid = 16232301 | doi = 10.1111/j.1600-0625.2005.00362.x | s2cid = 27700105 | doi-access = free }}
• {{cite journal | vauthors = Nehls M, Pfeifer D, Schorpp M, Hedrich H, Boehm T | title = New member of the winged-helix protein family disrupted in mouse and rat nude mutations | journal = Nature | volume = 372 | issue = 6501 | pages = 103–7 | date = Nov 1994 | pmid = 7969402 | doi = 10.1038/372103a0 | bibcode = 1994Natur.372..103N | s2cid = 2656526 }}
• {{cite journal | vauthors = Frank J, Pignata C, Panteleyev AA, Prowse DM, Baden H, Weiner L, Gaetaniello L, Ahmad W, Pozzi N, Cserhalmi-Friedman PB, Aita VM, Uyttendaele H, Gordon D, Ott J, Brissette JL, Christiano AM | title = Exposing the human nude phenotype | journal = Nature | volume = 398 | issue = 6727 | pages = 473–4 | date = Apr 1999 | pmid = 10206641 | doi = 10.1038/18997 | bibcode = 1999Natur.398..473F | hdl = 2299/16173 | s2cid = 107413 | hdl-access = free }}
• {{cite journal | vauthors = Gattenlöhner S, Müller-Hermelink HK, Marx A | title = Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors | journal = Pathology, Research and Practice | volume = 195 | issue = 8 | pages = 571–4 | year = 1999 | pmid = 10483588 | doi = 10.1016/s0344-0338(99)80007-7 }}
• {{cite journal | vauthors = Schlake T, Schorpp M, Maul-Pavicic A, Malashenko AM, Boehm T | title = Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype | journal = Developmental Dynamics | volume = 217 | issue = 4 | pages = 368–76 | date = Apr 2000 | pmid = 10767081 | doi = 10.1002/(SICI)1097-0177(200004)217:4<368::AID-DVDY4>3.0.CO;2-Z | doi-access = free }}
• {{cite journal | vauthors = Adriani M, Martinez-Mir A, Fusco F, Busiello R, Frank J, Telese S, Matrecano E, Ursini MV, Christiano AM, Pignata C | title = Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population | journal = Annals of Human Genetics | volume = 68 | issue = Pt 3 | pages = 265–8 | date = May 2004 | pmid = 15180707 | doi = 10.1046/j.1529-8817.2004.00091.x | s2cid = 20067101 }}
• {{cite journal | vauthors = Janes SM, Ofstad TA, Campbell DH, Watt FM, Prowse DM | title = Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt | journal = Journal of Cell Science | volume = 117 | issue = Pt 18 | pages = 4157–68 | date = Aug 2004 | pmid = 15316080 | doi = 10.1242/jcs.01302 | s2cid = 9153395 | url = http://discovery.ucl.ac.uk/6900/1/6900.pdf | doi-access = free }}
• {{cite journal | vauthors = Nonaka D, Henley JD, Chiriboga L, Yee H | title = Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms | journal = The American Journal of Surgical Pathology | volume = 31 | issue = 7 | pages = 1038–44 | date = Jul 2007 | pmid = 17592270 | doi = 10.1097/PAS.0b013e31802b4917 | s2cid = 30502411 }}
• {{cite journal | vauthors = Weiner L, Han R, Scicchitano BM, Li J, Hasegawa K, Grossi M, Lee D, Brissette JL | title = Dedicated epithelial recipient cells determine pigmentation patterns | journal = Cell | volume = 130 | issue = 5 | pages = 932–42 | date = Sep 2007 | pmid = 17803914 | doi = 10.1016/j.cell.2007.07.024 | s2cid = 14622851 | doi-access = free }}

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{{Transcription factors|g3}}

Category:Forkhead transcription factors

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