FOXN3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.{{cite journal |vauthors=Pati D, Keller C, Groudine M, Plon SE | title = Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA | journal = Mol Cell Biol | volume = 17 | issue = 6 | pages = 3037–46 |date=Jun 1997 | doi = 10.1128/MCB.17.6.3037 | pmid = 9154802 | pmc = 232156 }}{{cite web | title = Entrez Gene: CHES1 checkpoint suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1112}}
This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.
See also
References
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Further reading
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- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Field LL, Tobias R, Thomson G, Plon S |title=Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31. |journal=Genomics |volume=33 |issue= 1 |pages= 1–8 |year= 1996 |pmid= 8617492 |doi= 10.1006/geno.1996.0153 }}
- {{cite journal |vauthors=Hillier LD, Lennon G, Becker M |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal |vauthors=Yu Y, Zhang C, Zhou G |title=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 8 |pages= 1392–403 |year= 2001 |pmid= 11483580 |doi= 10.1101/gr.175501 | pmc=311073 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Heilig R, Eckenberg R, Petit JL |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 |bibcode=2003Natur.421..601H |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
- {{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 |display-authors=etal}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Scott KL, Plon SE |title=CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. |journal=Gene |volume=359 |pages= 119–26 |year= 2005 |pmid= 16102918 |doi= 10.1016/j.gene.2005.06.014 }}
- {{cite journal |vauthors=Busygina V, Kottemann MC, Scott KL |title=Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. |journal=Cancer Res. |volume=66 |issue= 17 |pages= 8397–403 |year= 2007 |pmid= 16951149 |doi= 10.1158/0008-5472.CAN-06-0061 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Katoh H, Ojima H, Kokubu A |title=Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets. |journal=Gastroenterology |volume=133 |issue= 5 |pages= 1475–86 |year= 2007 |pmid= 17983802 |doi= 10.1053/j.gastro.2007.08.038 |display-authors=etal|doi-access=free }}
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External links
- {{MeshName|CHES1+protein,+human}}
{{Transcription factors}}
Category:Forkhead transcription factors
{{gene-14-stub}}